期刊
CARBOHYDRATE POLYMERS
卷 211, 期 -, 页码 39-48出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2019.01.101
关键词
Dendrobium huoshanense polysaccharide; Type 2 diabetes; Hepatic glucose homeostasis; Pancreatic ss-cell function; Streptozocin
资金
- National Natural Science Foundation of China [21702040]
- Fundamental Research Funds for the Central Universities [JZ2017HGPB0169]
- Science and Technology Major Project of Anhui Province [18030801112, 17030701030]
In the present study, the hypoglycemic mechanism of a homogeneous Dendrobium huoshanense polysaccharide (GXG) was investigated using type 2 diabetic (T2D) mouse model. With a 5-week oral administration of GXG, the levels of fasting blood glucose, glycosylated serum protein and serum insulin in T2D mice were decreased, and the glucose tolerance and the insulin sensitivity were improved. The histological analysis, the periodic acid-schiff staining and the immunofluorescence staining of insulin, glucagon and apoptosis showed that the hypoglycemic effect of GXG was related to the improvement of pancreatic ss-cell quantity and function and the regulation of hepatic glucose metabolism. Western blot analysis indicated that the up-regulated IRS1-PI3K-Akt phosphorylation followed by the down-regulated FoxO1/GSK 3 ss phosphorylation contributed to the enhanced glycogen synthesis and the decreased gluconeogenesis by GXG, suggesting that the response of insulin-mediated IRS1-PI3K-Akt-FoxO1/GSK 3 ss signaling to GXG might be the required mechanism for GXG-ameliorated development of type 2 diabetes.
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