期刊
CANCER SCIENCE
卷 110, 期 7, 页码 2090-2099出版社
WILEY
DOI: 10.1111/cas.14075
关键词
CCL2; CCR2; inflammation; metastasis; propagermanium
类别
资金
- Japan Society for the Promotion of Science [17H05795, 17K07171, 18H05037]
- Japan Agency for Medical Research and Development [19cm0106105h0004]
- NAITO foundation
- Grants-in-Aid for Scientific Research [18H05037, 17H05795, 17K07171] Funding Source: KAKEN
Inflammation plays an essential role in the development and progression of most cancers. Chemokine C-C motif chemokine 2 (CCL2) and its receptor C-C chemokine receptor type 2 (CCR2) constitute a key signaling axis in inflammation that has recently attracted much interest on the basis of evidence showing its association with cancer progression. Propagermanium (3-oxygermylpropionic acid polymer) is an organogermanium compound that is given for the treatment of hepatitis B in Japan and which inhibits the CCL2-CCR2 signaling pathway. Herein, we review the importance of the CCL2-CCR2 axis as a target in cancer treatment as shown by studies in mice and humans with pharmacological agents including propagermanium.
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