期刊
CANCER LETTERS
卷 458, 期 -, 页码 1-12出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2019.05.030
关键词
FOXK1; FOXK2; ncRNAs; Biomarker; Therapeutic target
类别
资金
- National Natural Science Foundation of China [81702785, 81603026, 81802822]
- Natural Science Foundation of Shandong Province [ZR2017PH013, ZR2018BH017]
- Qingdao Postdoctoral Application Research Funded Project [2016067]
Growing evidence suggests that alterations of gene expression including expression and activities of transcription factors are closely associated with carcinogenesis. Forkhead Box Class K (FOXK) proteins, FOXK1 and FOXK2, are a family of evolutionarily conserved transcriptional factors, which have recently been recognized as key transcriptional regulators involved in many types of cancer. Members of the FOXK family mediate a wide spectrum of biological processes, including cell proliferation, differentiation, apoptosis, autophagy, cell cycle progression, DNA damage and tumorigenesis. Therefore, the deregulation of FOXKs can affect the cell fate and they promote tumorigenesis as well as cancer progression. The mechanisms of FOXKs regulation including post translational modifications (PTMs), microRNAs (miRNAs) and protein protein interactions are well demonstrated. However, the detailed mechanisms of FOXKs activation and deregulation in cancer progression are still inconclusive. In this review, we summarize the regulatory mechanisms of FOXKs expression and activity, and their role in the development and progression of cancer. We have discussed whether FOXKs act as tumor suppressors/oncoproteins in tumor cells and their therapeutic applications in malignant diseases are also discussed. This review may assist in designing experimental studies involving FOXKs and it would strength the therapeutic potential of FOXKs as targets for cancers.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据