期刊
CANCER IMMUNOLOGY IMMUNOTHERAPY
卷 68, 期 10, 页码 1681-1688出版社
SPRINGER
DOI: 10.1007/s00262-019-02330-y
关键词
Tumor-draining lymph node; Local immunotherapy; Cervical cancer; Melanoma; Breast cancer; TIMO 2018
资金
- Dutch Cancer Society (KWF Kankerbestrijding) [VU 2013-6015, VU 2015-7864]
Lymph nodes draining the primary tumor are essential for the initiation of an effective anti-tumor T-cell immune response. However, cancer-derived immune suppressive factors render the tumor-draining lymph nodes (TDLN) immune compromised, enabling tumors to invade and metastasize. Unraveling the different mechanisms underlying this immune escape will inform therapeutic intervention strategies to halt tumor spread in early clinical stages. Here, we review our findings from translational studies in melanoma, breast, and cervical cancer and discuss clinical opportunities for local immune modulation of TDLN in each of these indications.
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