期刊
CANCER CELL INTERNATIONAL
卷 19, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s12935-019-0824-z
关键词
Nectin-4; Esophageal cancer; Cancer progression; Prognosis
类别
资金
- National Key RD Program [2018YFC1313400]
- National Natural Science Foundation of Overseas Scholars Cooperation Research Project [31729001]
- National Natural Science Foundation of China [31570877, 31570908]
- Key R&D Project of Science and Technology Department of Jiangsu Province [BE2015633, BE2018645]
- Changzhou High-Level Medical Talents Training Project [2016CZBJ001]
BackgroundNectin-4, also known as PVRL4 (poliovirus-receptor-like 4), is specifically expressed in the embryo and placenta. Recent studies have reported that the Nectin-4 is over-expressed in multiple human cancers, and such abnormal expression is associated with cancer progression and poor prognosis of the patients. In the present study, we aimed to characterize the expression pattern of Nectin-4 in human esophageal cancer (EC) tissues, and to investigate its clinical implications, prognostic value and regulatory effects on cellular functions of EC cells.MethodsIn the present study, we first examined Nectin-4 expression in human EC tissues by using immunohistochemistry (IHC) assay and analyzed the clinical associations. Then the cellular studies in vitro and the nude mice tumor model in vivo were used to examine the regulatory role of Nectin-4 in the progression of EC.ResultsOur results demonstrated that over-expression of Nectin-4 in human EC tissues was significantly associated with tumor size, depth of tumor invasion, and poor prognosis of the patients. The intervention of Nectin-4 expression in EC cell lines showed that the increased Nectin-4 expression could significantly promote the cell viability, migration, invasion and tumor formation.ConclusionsOur present data unveiled that Nectin-4 played an important role in tumor biology and could serve as a useful prognostic predictor of human EC.
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