4.6 Article

Variability and directionality of inferior olive neuron dendrites revealed by detailed 3D characterization of an extensive morphological library

期刊

BRAIN STRUCTURE & FUNCTION
卷 224, 期 4, 页码 1677-1695

出版社

SPRINGER HEIDELBERG
DOI: 10.1007/s00429-019-01859-z

关键词

Dendritic morphometry; Sparse viral labeling; Network structure; Brainstem; Olivo-cerebellar system; Neuron reconstructions

资金

  1. Israel Science Foundation (ISF) [1496 2016]
  2. Dutch Organization for Medical Sciences (ZonMw)
  3. Life Sciences (ALW) [854.10.004]
  4. Neurotime, ERC-advanced program of the European Community [294775, 768914, 758914, 704922]
  5. Marie Curie Program (MSCA) [704922]
  6. Neurotime, ERC-PoC program of the European Community [294775, 768914, 758914, 704922]
  7. European Research Council (ERC) [768914, 294775] Funding Source: European Research Council (ERC)

向作者/读者索取更多资源

The inferior olive (IO) is an evolutionarily conserved brain stem structure and its output activity plays a major role in the cerebellar computation necessary for controlling the temporal accuracy of motor behavior. The precise timing and synchronization of IO network activity has been attributed to the dendro-dendritic gap junctions mediating electrical coupling within the IO nucleus. Thus, the dendritic morphology and spatial arrangement of IO neurons governs how synchronized activity emerges in this nucleus. To date, IO neuron structural properties have been characterized in few studies and with small numbers of neurons; these investigations have described IO neurons as belonging to two morphologically distinct types, curly and straight. In this work we collect a large number of individual IO neuron morphologies visualized using different labeling techniques and present a thorough examination of their morphological properties and spatial arrangement within the olivary neuropil. Our results show that the extensive heterogeneity in IO neuron dendritic morphologies occupies a continuous range between the classically described curly and straight types, and that this continuum is well represented by a relatively simple measure of straightness. Furthermore, we find that IO neuron dendritic trees are often directionally oriented. Combined with an examination of cell body density distributions and dendritic orientation of adjacent IO neurons, our results suggest that the IO network may be organized into groups of densely coupled neurons interspersed with areas of weaker coupling.

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