期刊
BRAIN STIMULATION
卷 12, 期 5, 页码 1229-1243出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.brs.2019.04.009
关键词
Somatosensory; Motor; Sensorimotor control; TMS; Paired-pulse TMS; Dual-site TMS
资金
- Canadian Institutes of Health Research (CIHR) [PDF 338973]
- Deutsche Forschungsgemeinschaft (DFG) [WE5919/1-1, SFB 936]
- University of Lubeck [H03-2016]
- Michael J. Fox foundation
- Else Kroner-Fresenius foundation [2018_A55]
- Parkinson Canada [2016-974]
- CIHR [357215, FRN 154292]
- Possehl-Stiftung
Background: Dual-site transcranial magnetic stimulation (ds-TMS) is a neurophysiological technique to measure functional connectivity between cortical areas. Objective/Hypothesis: To date, no study has used ds-TMS to investigate short intra-hemispheric interactions between the somatosensory areas and primary motor cortex (M1). Methods: We examined somatosensory-M1 interactions in the left hemisphere in six experiments using ds-TMS. In Experiment 1 (n = 16), the effects of different conditioning stimulus (CS) intensities on somatosensory-M1 interactions were measured with 1 and 2.5 ms inter-stimulus intervals (ISIs). In Experiment 2 (n = 16), the time-course of somatosensoy-M1 interactions was studied using supra-threshold CS intensity at 6 different ISIs. In Experiment 3 (n = 16), the time-course of short-interval cortical inhibition (SICI) and effects of different CS intensities on SICI were measured similar to Experiments 1 and 2. Experiment 4 (n = 13) examined the effects of active contraction on SICI and somatosensory-M1 inhibition. Experiments 5 and 6 (n = 10) examined the interactions between SAL with either 1 ms SICI or somatosensory-M1 inhibition. Results: Experiments 1 and 2 revealed reduced MEP amplitudes when applying somatosensory CS 1 ms prior to M1 TS with 140 and 160% CS intensities. Experiment 3 demonstrated that SICI at 1 and 2.5 ms did not correlate with somatosensory-M1 inhibition. Experiment 4 found that SICI but not somatosensory-M1 inhibition was abolished with active contraction. The results of Experiments 5-6 showed SAL was disinhibited in presence of somatosensory-M1 while SAL was increased in presence of SICI. Conclusion: Collectively, the results support the notion that the somatosensory areas inhibit the ipsilateral M1 at very short latencies. (C) 2019 Elsevier Inc. All rights reserved.
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