期刊
BRAIN PATHOLOGY
卷 29, 期 6, 页码 707-725出版社
WILEY
DOI: 10.1111/bpa.12729
关键词
autophagy; paediatric high grade glioma
资金
- Ollie Young Foundation
- Brain Tumour Research
- FCT Investigator contract from the Foundation for Science and Technology (FCT), Portugal [IF/00614/2014]
- FCT exploratory grant [IF/00614/2014/CP12340006]
- FCT Research Center Grant [UID/BIM/04773/2013CBMR1334]
Paediatric high-grade gliomas (pHGG) represent a therapeutically challenging group of tumors. Despite decades of research, there has been minimal improvement in treatment and the clinical prognosis remains poor. Autophagy, a highly conserved process for recycling metabolic substrates is upregulated in pHGG, promoting tumor progression and evading cell death. There is significant crosstalk between autophagy and a plethora of critical cellular pathways, many of which are dysregulated in pHGG. The following article will discuss our current understanding of autophagy signaling in pHGG and the potential modulation of this network as a therapeutic target.
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