期刊
BMC INFECTIOUS DISEASES
卷 19, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s12879-019-3990-7
关键词
Varicella; Fever-rash; Measles; Surveillance; Serostudy
资金
- Luxembourg Ministry of Foreign and European Affairs
- Luxembourg Institute of Health
BackgroundIn Lao PDR, the epidemiology of varicella infection is uncertain, since it is not a notifiable disease and VZV outbreaks are rarely reported as fever/rash (F/R) diseases.MethodsWe estimated the seroprevalence of VZV (IgG ELISA) in different age cohorts (9months to 46years; N=3139) and investigated VZV and 6 other viruses in patients during F/R outbreaks and in an ad hoc sentinel site in the context of the national reporting system (IgM ELISA, PCR).ResultsAt least 80% of the sampled population had evidence of VZV infection before the age of 15. The largest increase in seroprevalence occurred between the age groups 1 to 5 and 6 to 7year-olds. A VZV outbreak (clade 2) also occurred in this age group mostly during the first year of primary school (median age 6years, interquartile range 4.0-7.5). During a dengue outbreak, 6% had varicella. At our F/R sentinel site, 14% of children with viral etiology were laboratory diagnosed as varicella and among others, a sizeable number of measles (N=12) and rubella cases (N=25) was detected compared to those reported for the whole country (N=56 and 45), highlighting nationwide a large challenge of underreporting or misdiagnosis of these notifiable diseases because of lack of diagnostic laboratory capacity.ConclusionWe recommend strengthening the clinical and laboratory diagnosis of VZV, measles and rubella, the surveillance and reporting of notifiable F/R diseases by retraining of healthcare workers and by setting up sentinel sites and enhancing laboratory capacity.
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