期刊
BIOTECHNOLOGY JOURNAL
卷 14, 期 10, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/biot.201800528
关键词
extracellular vesicles (EVs); production; manufacturing; large scale; isolation
资金
- VES4US project - H2020-EU.1.2.1-FET Open programme [801338]
Potential applications of extracellular vesicles (EVs) are attracting increasing interest in the fields of medicine, cosmetics, and nutrition. However, the manufacturing of EVs is currently characterized by low yields. This limitation severely hampers progress in research at the laboratory and clinical scales, as well as the realization of successful and cost-effective EV-based products. Moreover, the high level of heterogeneity of EVs further complicates reproducible manufacturing on a large scale. In this review, possible directions toward the scalable production of EVs are discussed. In particular, two strategies are considered: i) the optimization of upstream unit operations and ii) the exploitation of well-established and mature technologies already in use in other industrial bioprocesses.
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