期刊
BIOSENSORS & BIOELECTRONICS
卷 131, 期 -, 页码 79-87出版社
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2019.02.008
关键词
Bi-BiOI@C; Surface plasmon resonance; Cathodic photocurrent; Aptasensor; Chloramphenicol
类别
资金
- National Natural Science Foundation of China [61571198]
- opening fund of Hubei Key Laboratory of Bioinorganic Chemistry Materia Medica [BCMM201704]
A novel p-type semiconductor-based cathodic signal-on photoelectrochemical (PEC) aptasensor was proposed for highly sensitive and selective detection of chloramphenicol (CAP). The photocathode was fabricated with hierarchical porous flower-like Bi-BiOI@C composite synthesized via a one-pot solvothermal method using glucose as both green reductant and carbon precursor. Due to the surface plasmon resonance (SPR) effect of Bi and high-conductivity of carbon, the composite exhibited an enhanced cathodic photocurrent as compared with pure BiOI or Bi-BiOI. When CAP-binding aptamer was immobilized as recognition element on Bi-BiOI@C modified electrode, a cathodic PEC aptasensor showing specific signal-on response to CAP was constructed. Some influencing factors such as coating amount of Bi-BiOI@C suspension, applied bias potential, and aptamer concentration were studied. Under the optimum conditions, the cathodic photocurrent of the constructed PEC aptasensor increased linearly with CAP concentration from 2 to 250 nM, with a detection limit (3S/N) of 0.79 nM. The proposed sensor was successfully applied to the determination of CAP in pharmaceutical tablet, eye drop and lake water samples.
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