期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 29, 期 9, 页码 1065-1068出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2019.03.003
关键词
Gold nanoparticles; PEI; Gold porphyrins; Colorectal cancer; Microwave
资金
- Conseil Regional de Nouvelle Aquitaine
A new gold nanoparticle-based construct has been designed to hydrophobic drugs delivery into cancer cells. Cyclodextrin scaffolds adsorbed on polyethyleneimine-coated gold nanoparticles (AuNP@PEI@CD) have been used to encapsulate hydrophobic tetrapyrrolic compounds consisting of gold complexes of 5,10,15,20-tetraphenyl porphyrin (AuTPPCl) and 5-(4-acetoxyphenyl)-10,15,20-triphenyl porphyrin (AuTPPOAcCl). These two nanoparticles have been tested for their cytotoxic activities against the two colorectal cancer cell lines HT-29 and HCT-116 and have shown significant increases in toxicity when compared to the corresponding non-vectorized tetrapyrrolic macrocycles.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据