期刊
BIOMEDICINE & PHARMACOTHERAPY
卷 112, 期 -, 页码 -出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2019.108623
关键词
MiR-378; K562 cell; Pluripotence; CML
资金
- National Natural Science foundation of China [81270630]
- Medical Innovation Team of Jiangsu Province [CXTDB2017002]
- Six talent peaks project in Jiangsu Province [2015-WSN-115]
- Liu Ge Yi Gong Cheng of Jiangsu Province [LGY2018024]
- China Postdoctoral Science Foundation [2016M601748]
- youth medical talents project of Ke Jiao Qiang Wei project of Jiangsu province [QNRC2016450]
- Zhenjiang Clinical Research Center of Hematology [SS2018009]
- Social Development Foundation of Zhenjiang [SH2018044]
- Social Development Foundation of Kunshan [KS1624]
Dysregulation of miR-378 has been found in diverse types of tumors as well as in leukemia. The role of miR-378 in chronic myeloid leukemia (CML) remains unclear. The aim of the study was to reveal the potential effects of miR-378 in the pathological process and progress in CML. Our results showed general level of miR-378 was significant higher in CML patients compared to controls. Overexpression of miR-378 dramatically promoted cell proliferation and drug-resistance. Additionally, apoptosis was inhibited in cells transfected with miR-378. More and bigger stem cell sphere formation was observed in miR-378 transfected cells. Furthermore, enhanced expression of miR-378 was associated with upregulation of stem-cell makers OCT4 and c-Myc. Further study validated that miR-378 inhibited the expression of FUS1. Our research demonstrated the oncogenic nature of miR-378 in CML, and might contribute to the progress of CML.
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