期刊
BIOMATERIALS
卷 201, 期 -, 页码 42-52出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2019.02.014
关键词
PTT; PDT; Temperature sensing; UC imaging; Dual modal therapy
资金
- National Natural Science Foundation of China [61775080, 81602659, 11874181, 61874049, 11674126, 11674127, 61674067]
- National Key Research and Development Program [2016YFC0207101]
- Special Project of the Province-University Co-constructing Program of Jilin Province [SXGJXX2017-3]
- Jilin Province Natural Science Foundation of China [20180101210JC, 20170101170JC, 20160418055FG]
- Jilin Province Science Fund for Excellent Young Scholars [20170520129JH, 20170520111JH]
Accurate treatment of photothermal therapy (PTT) is crucial to avoid the unnecessary injury of normal cells and tissues. Therefore the real-time temperature monitoring in the PTT process has drawn more and more attention in recent years. Herein, we designed and prepared one kind of lanthanide (Ln(3+))-doped up-conversion nano composites with multi-functions, which can not only provide temperature feedback in PTT process, but also play the photodynamic therapy (PDT) function for the synergistic effect of tumor therapy. Based on NaYF4:Yb, Er up-conversion nanoparticles (UCNPs), mesoporous SiO2 was modified on the surface combined with photosensitizer Chlorin e6 (Ce6) molecules, which could be excited by red emission of Er3+ under the 980 nm laser. Cit-CuS NPs were further linked on the surface of the composite served as photothermal conversion agent, therefore, the temperature of the PTT site can be monitored by recording the ratio of I-525/I-545 of green emissions, especially within the physiological range. Based on the guidance obtained from spectral experiments, we further investigated the dual-modal therapy effect both in vitro and in vivo, respectively, and acquired decent results.
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