期刊
BIOMARKERS IN MEDICINE
卷 13, 期 6, 页码 419-426出版社
FUTURE MEDICINE LTD
DOI: 10.2217/bmm-2018-0337
关键词
cancer stem cell; CD24; CD44; clinical significance of CD44 and CD24 in colorectal cancer; colorectal cancer; colorectal cancer stem cells; combined analysis; epithelial isoform; epithelial isoform of CD44; immunohistochemistry; invasion; tissue microarray
资金
- Iran University of Medical Sciences [95-02-126-28798]
Aim: There is no consensus regarding the clinical significance of CD44 and CD24 as cancer stem cell (CSC) marker in colorectal cancer (CRC). Methodology: A total of 494 CRC samples (2008-2017) were assessed for CD44 (epithelial isoform) and CD24 expression using tissue microarray. Results: CD24 individually or in combination with CD44 was not associated with any of the clinicopathologic characteristics of the tumor. CD44 expression was inversely associated with pathological Tumor, Node, Metastasis (pTNM) lower stages (p = 0.038) and lymphatic invasion (p = 0.05). Conclusion: In summary, the epithelial isoform of CD44 is inversely associated with invasive characteristics of CRC.
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