期刊
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
卷 1871, 期 2, 页码 259-266出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbcan.2019.01.006
关键词
Necroptosis; Cancer; Metastasis; RIPK3; MLKL
资金
- China's 1000 Young Talents Program
- National Natural Science Foundation of China [81773075]
- Shanghai International Cooperation and Exchange Project [18410720600]
Necroptosis is a programmed, caspasc-independent cell death that is morphologically similar to necrosis. Unlike apoptosis, necroptosis evokes inflammatory responses by releasing damage-associated molecular patterns. Recent studies suggest that tumor undergoes necroptosis in vivo and necroptosis has pro- or anti-tumoral effects in cancer development and progression. Furthermore, triggering necroptosis in tumor cells has been explored as a potential therapeutic strategy against cancer. Here, we will review the recent research progress of necroptosis in conferring anti- or pro-tumoral effects and its potential application in cancer therapy.
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