期刊
BEHAVIOURAL BRAIN RESEARCH
卷 371, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.bbr.2019.111982
关键词
Obsessive-Compulsive disorder (OCD); Resting-State functional magnetic resonance imaging (fMRI); Thalamic subregions; Fractional amplitude of low-frequency fluctuations (fALFF); Functional connectivity (FC)
资金
- NSFC-Henan mutual funds [U1704190]
- National Nature Science Foundation of China [81071091, 81571315, 31600927]
- Innovation Scientists and Technicians Troop Construction Projects of Henan Province [174100510024]
- Program for Innovative Research Team in Science and Technology in University of Henan Province [N-KFKT-10, 2016PN-KFKT-28]
- Open Program of the Henan Biological psychiatry key Laboratory [ZDSYS2014006, ZDSYS2015002]
- Postgraduate research and innovation support program of Xinxiang Medical University [YJSCX201730Y]
The thalamus plays an important role in pathological mechanisms underlying obsessive-compulsive disorder (OCD). As the thalamus is a heterogeneous brain region, functional connectivity (FC) between thalamic sub-regions and other brain regions is worth investigating in OCD. In addition, the relationship between abnormal FC and clinical symptoms is still unclear. In this study, we used resting-state functional magnetic resonance imaging to scan 45 OCD patients and 43 well-matched healthy controls (HCs). Thalamic subregions were defined according to the Human Brainnetome Atlas. The fractional amplitude of low-frequency fluctuations (fALFF) and FC seeding-based connectivity were compared using a two-sample t-test. Correlations between abnormal FC and clinical symptoms were analyzed in OCD patients. Compared with HCs, increased fALFF was found in the bilateral thalamus, and increased FC was observed between the right posterior parietal thalamus (PPtha) and left middle occipital gyrus (LMOG) and between the right occipital thalamus (Otha) and right middle occipital gyrus (RMOG) in OCD patients. In addition, OCD patients had reduced FC between the left sensory thalamus (Stha) and left orbital inferior frontal gyrus, right PPtha and left prefrontal cortex, and between the right Otha and left inferior parietal gyrus (LIPG), respectively. Within the OCD group, the FC between right PPtha-LMOG was correlated with severity of clinical symptoms. These results revealed that the FC between the thalamus and occipital lobe is related to obsessive-compulsive symptoms in OCD patients. This finding provides more accurate information about the involvement of the thalamus in the pathophysiology of OCD.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据