期刊
ARCHIVES OF PHARMACAL RESEARCH
卷 42, 期 6, 页码 512-518出版社
PHARMACEUTICAL SOC KOREA
DOI: 10.1007/s12272-019-01151-y
关键词
ent-Abietane diterpenoids; Euphorbia fischeriana; Structural elucidation; Cytotoxicity
资金
- Program for Foundation of Health and Family Planning Commission of Hubei Province [WJ2017F079]
- Soft Science Project of Taihe Hospital [2017rkt12]
Three new ent-abietane diterpenoids, termed fischerianoids A-C (1-3), were isolated and identified from the ethyl acetate extracts of roots of the medicinally valuable plant Euphorbia fischeriana. The planar and relative structures of 1-3 were established via high-resolution electrospray ionisation mass spectrometry and one- and two-dimensional nuclear magnetic resonance spectroscopic analyses, and the absolute configuration of 1 was further established via X-ray crystallography experiment. Compounds 1-3 showed selective inhibitory potency against certain human tumor cell lines with IC50 values ranging from 8.500.13 to 35.52 +/- 0.08 mu M. [GRAPHICS] .
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