Sex differences in psychosocial and cardiometabolic health among patients completing cardiac rehabilitation

Current programs of cardiac rehabilitation (CR) typically provide a standardized approach to all patients. We examined whether CR would produce similar improvements in psychosocial and cardiometabolic health indicators in women compared with men. The records of patients who completed a 3-month outpatient CR program were examined. We compared health-related quality of life (i.e., Physical Component Summary (PCS) and Mental Component Summary (MCS) scores), anxiety, depression, and cardiometabolic health indicators between women and men completing CR. Of the 591 participants who completed CR, 155 (26.2%) were women and 436 (73.8%) were men. At baseline, women were older (64 +/- 9 vs. 62 +/- 9 years, p = 0.045), had lower PCS (39.5 +/- 8.1 vs. 43.9 +/- 7.8 points, p < 0.001), and MCS (46.6 +/- 10.8 vs. 49.4 +/- 9.8 points, p = 0.003) scores, experienced elevated levels of anxiety (6.4 +/- 4.0 vs. 5.2 +/- 4.0 points, p = 0.001) and depression (4.7 +/- 3.5 vs. 3.6 +/- 3.3 points, p= 0.001), and had higher low-density lipoprotein cholesterol (2.1 +/- 0.9 vs. 1.7 +/- 0.7 mmol/L, p < 0.001) and high-density lipoprotein cholesterol (1.4 +/- 0.4 vs. 1.1 +/- 0.3 mmol(L, p < 0.001) concentrations when compared with men. Following CR, women showed smaller improvements in percent body mass (+1.1% +/- 10.1% vs. -2.1% +/- 9.7%, p = 0.002) and PCS scores (3.0 +/- 8.1 vs. 6.3 +/- 7.5 points, p < 0.001) when compared with men. Considering poorer psychosocial health at baseline and smaller improvements in health-related quality of life in women when compared with men, more specific CR strategies addressing the particular needs of women are required to improve their health status and reduce the risk of secondary cardiac events.