期刊
ANTICANCER RESEARCH
卷 39, 期 4, 页码 2025-2033出版社
INT INST ANTICANCER RESEARCH
DOI: 10.21873/anticanres.13313
关键词
Oral cavity; squamous cell carcinoma; prognosis; SCC antigen; C-reactive protein; CYFRA 21-1
类别
资金
- Chang Gung Memorial Hospital [CMRPG3H0791, CMRPB53]
- National Science Council, Executive Yuan, Taiwan, ROC [MOST106-2314-B-182-025-MY3]
- Health and Welfare Surcharge on Tobacco Products from the Ministry of Health and Welfare (MOHW), Executive Yuan, Taiwan, ROC [MOHW108-TDU-B-212-124016]
Background/Aim: Tumor-related and inflammationrelated markers were reported to be prognostic in cancer patients. In this study, we evaluated squamous cell carcinoma antigen (SCC-Ag), cytokeratin 19 fragment (CYFRA 21-1) and C-reactive protein (CRP) simultaneously in oral cavity squamous cell carcinoma (OSCC) patients. Patients and Methods: Two hundred and forty-six newly diagnosed OSCC patients were retrospectively recruited between December 2010 and December 2016. Results: The elevation of CRP levels (>= 5.0 mg/l) and SCC-Ag levels (>= 2.0 ng/ml) were significantly related with tumor invasion parameters and metastatic factors. In contrast, the elevation of CYFRA 21-1 levels (>= 3.3 ng/ml) was related with extranodal extension alone. For patients with all three markers being elevated before surgery, their overall survival and disease-free survival were significantly worse than others. Conclusion: Concurrent elevation of preoperative SCCAg, CYFRA 21-1 and CRP serum levels can be correlated with worse survival rates in OSCC.
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