期刊
ANNUAL REVIEW OF NUTRITION, VOL 39, 2019
卷 39, 期 -, 页码 175-200出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-nutr-082018-124344
关键词
bile acid signaling; bile acid therapy; nonalcoholic fatty liver disease; FXR; TGR5
资金
- NIDDK NIH HHS [R01 DK058379, R37 DK058379, R01 DK044442, R56 DK044442] Funding Source: Medline
Bile acids facilitate nutrient absorption and are endogenous ligands for nuclear receptors that regulate lipid and energy metabolism. The brain-gut-liver axis plays an essential role in maintaining overall glucose, bile acid, and immune homeostasis. Fasting and feeding transitions alter nutrient content in the gut, which influences bile acid composition and pool size. In turn, bile acid signaling controls lipid and glucose use and protection against inflammation. Altered bile acid metabolism resulting from gene mutations, high-fat diets, alcohol, or circadian disruption can contribute to cholestatic and inflammatory diseases, diabetes, and obesity. Bile acids and their derivatives are valuable therapeutic agents for treating these inflammatory metabolic diseases.
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