期刊
ANNUAL REVIEW OF MICROBIOLOGY, VOL 73
卷 73, 期 -, 页码 43-67出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-micro-020518-115907
关键词
RNA-binding protein; gene regulation; attenuation; antitermination; translation; sRNA
类别
资金
- NIGMS NIH HHS [R01 GM066794, R01 GM098399, R01 GM059969] Funding Source: Medline
RNA-binding proteins play vital roles in regulating gene expression and cellular physiology in all organisms. Bacterial RNA-binding proteins can regulate transcription termination via attenuation or antitermination mechanisms, while others can repress or activate translation initiation by affecting ribosome binding. The RNA targets for these proteins include short repeated sequences, longer single-stranded sequences, RNA secondary or tertiary structure, and a combination of these features. The activity of these proteins can be influenced by binding of metabolites, small RNAs, or other proteins, as well as by phosphorylation events. Some of these proteins regulate specific genes, while others function as global regulators. As the regulatory mechanisms, components, targets, and signaling circuitry surrounding RNA-binding proteins have become better understood, in part through rapid advances provided by systems approaches, a sense of the true nature of biological complexity is becoming apparent, which we attempt to capture for the reader of this review.
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