期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 58, 期 23, 页码 7647-7651出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201901501
关键词
asymmetric relay catalysis; C1-ammonium enolates; carbonylation; cascade reactions; palladium
资金
- NSFC [21831007, 21772184]
- 973 Program [2015CB856602]
- Chinese Academy of Science [XDB20000000]
A general strategy for the design of asymmetric cascade reactions using readily available halides and carbon monoxide (CO) as substrates is developed. The key is the catalytic generation of C1-ammonium enolates for the subsequent asymmetric cascade reactions through the combination of palladium-catalyzed carbonylation and chiral Lewis base catalysis. Utilizing this strategy, we have established asymmetric formal [1+1+4] and [1+1+2] reactions to afford chiral dihydropyridones and beta-lactams with high yields and high enantio- and diastereoselectivities.
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