期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 58, 期 31, 页码 10752-10755出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201903479
关键词
aptamers; clickmers; receptor-guided design strategy; SELEX; THC
资金
- Deutsche Forschungsgemeinschaft [MA 3442/4-2] Funding Source: Medline
- BMWi-ZIM [KF3058901SK2] Funding Source: Medline
Biomedical sciences require effective tools to manipulate, detect, and study biological phenomena. Oligo(deoxy)nucleotide ligands represent such tools, but the current strategies to generate them are restricted. Their limited availability is insufficient to address the broad range of targets related to biomedical research. Exemplified by targeting the hydrophobic molecule (-)-Delta(9)-tetrahydrocannabinol (THC), we report a receptor-guided design (RGD) strategy to generate chemically modified oligodeoxynucleotide libraries for the tailored selection of clickmers.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据