期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 58, 期 25, 页码 8531-8535出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201904530
关键词
hydrogenative acylation; keteniminates; reductive C-C coupling; ruthenium; alpha; beta-unsaturated nitriles
资金
- NSF [CHE-1350877, CHE 1625543]
- Rackham Graduate Student Research Grant
We present an atom-economic strategy to catalytically generate and intercept nitrile anion equivalents using hydrogen transfer catalysis. Addition of alpha,beta-unsaturated nitriles to a pincer-based Ru-H complex affords structurally characterized kappa-N-coordinated keteniminates by selective 1,4-hydride transfer. When generated insitu under catalytic hydrogenation conditions, electrophilic addition to the keteniminate was achieved using anhydrides to provide alpha-cyanoacetates in high yields. This work represents a new application of hydrogen transfer catalysis using alpha,beta-unsaturated nitriles for reductive C-C coupling reactions.
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