期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 58, 期 46, 页码 16368-16388出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201902216
关键词
concerted reactions; cS(N)Ar mechanism; Meisenheimer complex; nucleophilic aromatic substitution
资金
- EPSRC [EP/N509371/1]
- GSK
- University of Strathclyde
- Nanyang Technological University Singapore
- Royal Society [IES\R3\170027]
- Singapore Ministry of Education [RG10/17]
Recent developments in experimental and computational chemistry have identified a rapidly growing class of nucleophilic aromatic substitutions that proceed by concerted (cS(N)Ar) rather than classical, two-step, SNAr mechanisms. Whereas traditional SNAr reactions require substantial activation of the aromatic ring by electron-withdrawing substituents, such activating groups are not mandatory in the concerted pathways.
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