期刊
ANALYTICAL CHEMISTRY
卷 91, 期 11, 页码 7466-7473出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.9b01674
关键词
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资金
- Universiti Sains Malaysia via Short Term Grant [303/PKIMIA/6313303]
- French Embassy in Malaysia
- Agence Nationale de la Recherche [ANR-14-CE14-0002-01]
A new sample preparation method is proposed for the extraction of pharmaceutical compounds (Metformin, Phenyl biguanide, and Phenformin) of varied hydrophilicity, dissolved in an aqueous sample. When in contact with an organic phase, an interfacial potential is imposed by the presence of an ion, tetramethylammonium (TMA(+)), common to each phase. The interfacial potential difference drives the transfer of ionic analytes across the interface and allows it to reach up to nearly 100% extraction efficiency and a 60-fold enrichment factor in optimized extraction conditions as determined by HPLC analysis.
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