期刊
ANALYTICAL CHEMISTRY
卷 91, 期 12, 页码 7705-7711出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.9b00889
关键词
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资金
- DST
- CSIR-UGC
- NIPER, Kolkata
Herein, we develop a competitive screening method in which G-quadruplex DNA linked magnetic nanoparticles pull down selective ligands for a particular quadruplex topology from a series of small molecules. The screening strategy is first optimized with known G-quadruplex ligands and then used with a new series of G-quadruplex interactive bis-triazolyl ligands that are synthesized by Cu(I)-catalyzed azide alkyne cycloaddition. The assay enables the identification of c-MYC and BCL2 G-quadruplex selective bis-triazole ligands that specifically target promoter G-quadruplexes in cancer cells.
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