期刊
ALZHEIMERS & DEMENTIA
卷 15, 期 6, 页码 840-858出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jalz.2019.01.013
关键词
Cerebral small vessel disease; Dementia; Blood-brain barrier; Endothelial dysfunction; DCE-MRI; Permeability; MRI
资金
- European Union Joint Programme-Neurodegenerative Disease Research Working Groups for Harmonisation and Alignment in Brain Imaging Methods for Neurodegeneration
- European Union [666881]
- SVDs@Target, The Fondation Leducq [16 CVD 05]
- Medical Research Council
- NHS Lothian Research and Development Office
- Alzheimer Nederland
- Stichting De Weijerhorst
- Academisch Fonds
- Nederlands Wetenschappelijk Onderzoek
- Hersenstichting organization
- MRC [UKDRI-4002] Funding Source: UKRI
Cerebral small vessel disease (cSVD) comprises pathological processes of the small vessels in the brain that may manifest clinically as stroke, cognitive impairment, dementia, or gait disturbance. It is generally accepted that endothelial dysfunction, including blood-brain barrier (BBB) failure, is pivotal in the pathophysiology. Recent years have seen increasing use of imaging, primarily dynamic contrast-enhanced magnetic resonance imaging, to assess BBB leakage, but there is considerable variability in the approaches and findings reported in the literature. Although dynamic contrast-enhanced magnetic resonance imaging is well established, challenges emerge in cSVD because of the subtle nature of BBB impairment. The purpose of this work, authored by members of the HARNESS Initiative, is to provide an in-depth review and position statement on magnetic resonance imaging measurement of subtle BBB leakage in clinical research studies, with aspects requiring further research identified. We further aim to provide information and consensus recommendations for new investigators wishing to study BBB failure in cSVD and dementia. (C) 2019 The Authors. Published by Elsevier Inc. on behalf of the Alzheimer's Association. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
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