期刊
AGING CELL
卷 18, 期 4, 页码 -出版社
WILEY
DOI: 10.1111/acel.12956
关键词
cellular senescence; human; immunosenescence; skin aging
资金
- European Union [FP6 036894, DFG-PA 361/14-1, DFG-SFB685-B4, DFG-PA 361/11-1]
- Innovation Oriented Research Program on Genomics [IGE01014, IGE5007]
- Centre for Medical Systems Biology, The Netherlands Genomics Initiative/Netherlands Organization for Scientific Research [05040202, 050-060-810]
- Deutsche Forschungsgemeinschaft
- Unilever PLC
- IDEAL
- Novo Nordisk Fonden [17OC0027812]
With advancing age, many organs exhibit functional deterioration. The age-associated accumulation of senescent cells is believed to represent one factor contributing to this phenomenon. While senescent cells are found in several different organ systems, it is not known whether they arise independently in each organ system or whether their prevalence within an individual reflects that individual's intrinsic aging process. To address this question, we studied senescence in two different organ systems in humans, namely skin and T cells in 80 middle-aged and older individuals from the Leiden Longevity Study. Epidermal p16INK4a positivity was associated with neither CD4(+) nor CD8(+) T-cell immunosenescence phenotype composites (i.e., end-stage differentiated/senescent T cells, including CD45RA(+)CCR7(-)CD28(-)CD27(-)CD57(+)KLRG1(+) T cells). Dermal p16INK4a positivity was significantly associated with the CD4(+), but not with the CD8(+) immunosenescence composite. We therefore conclude that there is limited evidence for a link between skin senescence and immunosenescence within individuals.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据