期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 361, 期 15, 页码 3569-3574出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201900426
关键词
Gold-Catalysis; Alkyne Annulation; Alkyne Oxoarylation; Cascade Reaction
资金
- National Natural Science Foundation of China and Jiangsu province [21602148]
- National Science & Technology Major Project Key New Drug Creation and Manufacturing Program of China [2018ZX09711002-006]
- Program for Guangdong Introducing Innovative and Entrepreneurial Teams [2016ZT06Y337]
- National Natural Science Foundation of China
An unprecedented gold-catalyzed dual annulation of homopropargyl alcohols with nitrones has been developed, which provides an effective access to the 1,3,4,5-tetrahydropyrano[4,3-b]indole derivatives in good to high yields. Mechanistically, this one-pot three-step cascade reaction is initiated by a gold-catalyzed alkyne oxoarylation, followed by an intramolecular cyclodehydration and terminated with an intermolecular cyclization with aldehyde which is a leaving species in the early stage of this cascade process.
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