期刊
ADVANCED MATERIALS
卷 31, 期 27, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201901592
关键词
drug delivery; metal-organic frameworks; micromachines; pH-responsive materials; ZIF-8
类别
资金
- China Scholarship Council [201504910817]
- ETH through the project MOFBOTs [ETH-33-17-1]
- Swiss National Science Foundation [200021_181988]
- EU [677020, 771565]
- Swiss Secretariat of Research and Innovation [642642]
- Ministry of Science and ICT [NRF-2017K1A1A2013237]
- [LP-03]
- Swiss National Science Foundation (SNF) [200021_181988] Funding Source: Swiss National Science Foundation (SNF)
Motile metal-organic frameworks (MOFs) are potential candidates to serve as small-scale robotic platforms for applications in environmental remediation, targeted drug delivery, or nanosurgery. Here, magnetic helical microstructures coated with a kind of zinc-based MOF, zeolitic imidazole framework-8 (ZIF-8), with biocompatibility characteristics and pH-responsive features, are successfully fabricated. Moreover, it is shown that this highly integrated multifunctional device can swim along predesigned tracks under the control of weak rotational magnetic fields. The proposed systems can achieve single-cell targeting in a cell culture media and a controlled delivery of cargo payloads inside a complex microfluidic channel network. This new approach toward the fabrication of integrated multifunctional systems will open new avenues in soft microrobotics beyond current applications.
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