期刊
ADVANCED FUNCTIONAL MATERIALS
卷 29, 期 24, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.201900603
关键词
ferrimagnetic iron oxide nanochains; genetic engineering; ischemic cerebrum homing; mesenchymal stem cells; post-stroke recovery
类别
资金
- National Key Research and Development Program of China [2016YFA0203600]
- National Natural Science Foundation of China [31822019, 81620108028, 81703423, 91859116, 51703195, 81473143]
- One Belt and One Road International Cooperation Project from Key Research and Development Program of Zhejiang Province [2019C04024]
- China Postdoctoral Science Foundation [2018M640568, 2016M601938]
- Fundamental Research Funds for the Central Universities [2018QNA7021, 2018QNA7020]
- Zhejiang Provincial Natural Science Foundation of China [LGF19C100002]
- Thousand Talents Program for Distinguished Young Scholars
- Research Center Program of Institute for Basic Science in Korea [IBS-R006-D1]
- National Research Foundation of Korea [IBS-R006-D1-2019-A00] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Unsatisfactory post-stroke recovery has long been a negative factor in the prognosis of ischemic stroke due to the lack of pharmacological treatments. Mesenchymal stem cells (MSCs)-based therapy has recently emerged as a promising strategy redefining stroke treatment; however, its effectiveness has been largely restricted by insufficient therapeutic gene expression and inadequate cell numbers in the ischemic cerebrum. Herein, a non-viral and magnetic field-independent gene transfection approach is reported, using magnetosome-like ferrimagnetic iron oxide nanochains (MFIONs), to genetically engineer MSCs for highly efficient post-stroke recovery. The 1D MFIONs show efficient cellular uptake by MSCs, which results in highly efficient genetic engineering of MSCs to overexpress brain-derived neurotrophic factor for treating ischemic cerebrum. Moreover, the internalized MFIONs promote the homing of MSCs to the ischemic cerebrum by upregulating CXCR4. Consequently, a pronounced recovery from ischemic stroke is achieved using MFION-engineered MSCs in a mouse model.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据