期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 149, 期 -, 页码 2-18出版社
ELSEVIER
DOI: 10.1016/j.addr.2019.03.006
关键词
Chronic wound; Diabetic foot ulcer; Venous leg ulcer; Pressure ulcer; Scaffold; Hydrogel; Sponge; Foam; Layer by layer
资金
- SUG from NTU
- MOE T1 grant [T1-002-098, T1-002013]
- BMRC IAFPP Wound Care Innovation in the Tropics
- A*Star-SHGNTU Skin Research Grant [15005]
- NTU IGS studentship
Acute wound healing is an orderly process of four overlapping events: haemostasis, inflammation, proliferation and remodelling. A drug delivery system with a temporal control of release could promote each of these events sequentially. However, acute wound healing normally proceeds very well in healthy individuals and there is little need to promote it. In the elderly and diabetics however, healing is often slow and wounds can become chronic and we need to promote their healing. Targeting the events of acute wound healing would not be appropriate for a chronic wound, which have stalled in the proinflammatory phase. They also have many additional problems such as poor circulation, low oxygen, high levels of leukocytes, high reactive oxygen species, high levels of proteolytic enzymes, high levels of proinflammatory cytokines, bacterial infection and high pH. The future challenge will be to tackle each of these negative factors to create a wound environment conducive to healing. (C) 2019 Elsevier B.V. All rights reserved.
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