期刊
ACS APPLIED MATERIALS & INTERFACES
卷 11, 期 21, 页码 18978-18987出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.9b04792
关键词
nanoclusters; drug delivery; paclitaxel; nanodiamond; self-assembled supraparticles; poly(ethylene glycol)
资金
- Daicel Corporation
- Japan Society for the Promotion of Science (JSPS) KAKENHI [19H00857]
- JSPS KAKENHI Fund for the Promotion of Joint International Research (Fostering Joint International Research) [16KK0117]
- JSPS KAKENHI [16H03834]
- Grants-in-Aid for Scientific Research [16KK0117, 16H03834, 19H00857] Funding Source: KAKEN
Nanodiamonds (NDs) have been attracting considerable attention due to their outstanding chemical, physical, and physiological properties. Additional functionalization of NDs can be carried out by the self-assembly technique. This study reports a straightforward chemical route for self-assembled supraparticles (SPs) based on ND (ND-SPs) using alkyl carboxylic acids with different aliphatic alkyl chain lengths by carbodiimide chemistry and sonication. Poly(ethylene glycol) (PEG)-modified ND SPs are synthesized successfully for effective nanodrug formulations with the hydrophobic anticancer drug paclitaxel (PTX). The properties of these ND-SP nanomedicines are investigated thoroughly by complementary analytical, spectroscopic, and microscopic techniques. This simple methodology permitted the application of PEG-modified ND-SP-encapsulating PTX as a potent drug carrier, achieving greater efficacy than commercial Abraxane. Results revealed that the morphology, particle size, and water dispersibility of the prepared ND-SP nanoclusters affect the drug efficacy. These PEG-modified ND-SP nanoclusters serve as novel nanomedicine for a passive drug delivery system as well as anticancer chemotherapy.
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