期刊
ACS APPLIED MATERIALS & INTERFACES
卷 11, 期 30, 页码 26529-26558出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.9b01370
关键词
cancer therapy; organelle-targeted; nucleus; mitochondrion; endoplasmic reticulum; lysosome; Golgi apparatus; nanodrugs
资金
- National Natural Science Foundation of China [21535004, 91753111, 21874086, 21775094]
- Key Research and Development Program of Shandong Province [2018YFJH0502]
The ultimate goal of cancer therapy is to eliminate malignant tumors while causing no damage to normal tissues. In the past decades, numerous nanoagents have been employed for cancer treatment because of their unique properties over traditional molecular drugs. However, lack of selectivity and unwanted therapeutic outcomes have severely limited the therapeutic index of traditional nanodrugs. Recently, a series of nanomaterials that can accumulate in specific organelles (nucleus, mitochondrion, endoplasmic reticulum, lysosome, Golgi apparatus) within cancer cells have received increasing interest. These rationally designed nanoagents can either directly destroy the subcellular structures or effectively deliver drugs into the proper targets, which can further activate certain cell death pathways, enabling them to boost the therapeutic efficiency, lower drug dosage, reduce side effects, avoid multidrug resistance, and prevent recurrence. In this Review, the design principles, targeting strategies, therapeutic mechanisms, current challenges, and potential future directions of organelle-targeted nanomaterials will be introduced.
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