期刊
ACS APPLIED MATERIALS & INTERFACES
卷 11, 期 25, 页码 22096-22101出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.9b03004
关键词
Fe-MOF; nanozymes; cascade reactions; colorimetric biosensing; glucose detection
资金
- Fundamental Research Funds for the Central Universities [CCNU19QN066]
- Program of Introducing Talents of Discipline to Universities of China (111 program) [B17019]
- Recruitment Program of Global Youth Experts of China
Nanozyme/natural enzyme hybrid plays a vital role in biosensing, therapy, and catalysis owing to the integrated advantages in the selectivity of natural enzymes and controllable catalytic activity of nanozymes. Herein, Fe-MIL-88B-NH2 [(Fe-metal organic framework (MOF)] with remarkable peroxidase-like activity, ultrahigh stability, and high biocompatibility was utilized for immobilization of glucose oxidase (GOx) via an amidation coupling reaction. On the basis of the excellent selectivity and catalytic activity of Fe-MOF-GOx, a cascade catalysis was performed for the colorimetric detection of glucose. The integrated Fe-MOF-GOx not only exhibited higher stability and reusability than their mixtures including Fe-MOF and free GOx system but also possessed a wide linear range (1-500 mu M), with a low detection limit of 0.487 mu M for glucose detection.
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