期刊
ACS APPLIED MATERIALS & INTERFACES
卷 11, 期 19, 页码 17697-17705出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.9b03942
关键词
nanosurface engineering; isothermal titration calorimetry; molecular dynamics; association models; cystein-containing peptides; silver nanoparticles; polydispersity
资金
- Natural Sciences and Engineering Research Council (NSERC) [RGPIN-2015-0632]
- Canadian Institutes of Health Sciences (CIHR)
- NSERC [RGPIN-2015-06503]
- CIHR [PJT-148869, PJT-148533]
- FONDECYT [1171155]
- Millennium Nucleus of Ion Channel Associated Diseases (MiNICAD), the Millennium Nucleus - Iniciativa Cientifica Milenio of the Ministry of Economy, Development and Tourism (Chile)
- Secyt-UNC [411/18]
- Natural Sciences and Engineering Research Council Undergraduate Student Research Award
- Queen Elizabeth II Graduate Scholarship in Science and Technology
The effect of accounting for the total surface in the association of thiol-containing molecules to nanosilver was assessed using isothermal titration calorimetry, along with a new open access algorithm that calculates the total surface area for samples of different polydispersity. Further, we used advanced molecular dynamic calculations to explore the underlying mechanisms for the interaction of the studied molecules in the presence of a nanosilver surface in the form of flat surfaces or as three-dimensional pseudospherical nano structures. Our data indicate that not only is the total surface area available for binding but also the supramolecular arrangements of the molecules in the near proximity of the nanosilver surface strongly affects the affinity of thiol-containing molecules to nanosilver surfaces.
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