期刊
ACS APPLIED MATERIALS & INTERFACES
卷 11, 期 19, 页码 17306-17312出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.9b04269
关键词
forensic science; aggregation-induced emission; bloodstain detection; thiol probe; public security
资金
- National Science Foundation of China [21788102, 81871523]
- Research Grants Council of Hong Kong [16308016, 16305015, N-HKUST604/14, C2014-15G, C6009-17G]
- Innovation and Technology Commission [ITC-CNERC14SC01, ITCPD/17-9, ITS/254/17]
- Science and Technology Plan of Shenzhen [JCYJ20160229205601482, JCYJ20160428150429072]
- Program for Young Innovative Research Team in China University of Political Science and Law [18CXTD09, 16CXTD05]
- Start-Up Grant of the City University of Hong Kong [7200600]
Bloodstains provide admissible information for crime scene investigators. The ability to resolve latent bloodstains that are commonly found in real scenarios is therefore pivotal to public security. Here, we report a facile approach for invisible bloodstain visualization based on the click reaction between serum albumin and tetraphenylethene maleimide (TPE-MI), an aggregation induced emission luminogen (AIEgen). Compared to the widely adopted methods based on the harsh catalytic oxidation activity of hemoglobin, this working principle benefits from the specificity of the mild catalyst-free thiol-ene click reaction that improves the reliability and resolution. In addition, the mild conditions preserve DNA information and bloodstain patterns, and the excellent photophysical properties of the AIEgen afford high sensitivity and stability (>1 yr). Such an excellent performance cannot be achieved by conventional AIEgens and aggregation-caused quenching luminogens with similar structures. TPE-MI outperforms the benchmark luminol-based technique in visualizing latent bloodstains as showcased in two mock crime scenes: spattered blood track and transfer blood fingerprint. This disclosed method is an advancement in forensic science that could inspire future development of technology for bloodstain visualization.
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