期刊
ACS APPLIED MATERIALS & INTERFACES
卷 11, 期 17, 页码 15262-15275出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.9b00897
关键词
small molecular drug coassemblies; biomimetic red blood cell membranes; light/pH-response; on-demand drug release; chemo-PTT therapy
资金
- National Natural Science Foundation of China [31271071]
- Health Commission of Jiangsu Province of China [H2018070]
- Double-First Class Foundation of Materials and Intelligent Manufacturing Discipline of Xiamen Univ.
Nanoparticles camouflaged by red blood cell (RBC) membranes have attracted considerable attention owing to reservation of structure of membrane and surface proteins, endowing prominent cell-specific function including biocompatibility, prolonged circulation lifetime, and reduced reticular endothelial system (RES) uptake ability. Considering the drawbacks of carrier-free nanomedicine including the serious drug burst release, poor stability, and lack of immune escape function, herein we developed and fabricated a novel RBC membranes biomimetic combinational therapeutic system by enveloping the small molecular drug coassemblies of 10-hydroxycamptothecin (10-HCPT) and indocyanine green (ICG) in the RBC membranes for prolonged circulation, controlled drug release, and synergistic chemo-photothermal therapy (PTT). The self-reorganized RBC5@ICG-HCPT nanoparticles (NPs) exhibited a diameter of similar to 450 nm with core-shell structure, high drug payload (similar to 92 wt %), and reduced RES uptake function. Taking advantage of the stealth functionality of RBC membranes, RBC5@ICG-HCPT NPs remarkably enhanced the accumulation at the tumor sites by passive targeting followed by cellular endocytosis. Upon the stimuli of near-infrared laser followed by acidic stimulation, RBCs@ICG-HCPT NPs showed exceptional instability by heat-mediated membrane disruption and pH change, thereby triggering the rapid disassembly and accelerated drug release. Consequently, compared with individual treatment, RBCs@ICG-HCPT NPs under dual-stimuli accomplished highly efficient apoptosis in cancer cells and remarkable ablation of tumors by chemo-PTT. This biomimetic nanoplatform based on carrier-free, small molecular drug coassemblies integrating imaging capacity as a promising theranostic system provides potential for cancer diagnosis and combinational therapy.
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