Multilinker phosphorous acid anchored En/MIL-100(Cr) as a novel nanoporous catalyst for the synthesis of new N-heterocyclic pyrimido[4,5-b] quinolines

A novel ethylenediamine (En) based metal-organic frameworks (MOFs) of Cr-MOFs, En/MIL-100(Cr), containing phosphorous acid tags was prepared. MIL-100(Cr)/NHEtN(CH2PO3H2)(2) characterized by a variety of techniques, including fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), elemental mapping and energy dispersive X-ray (EDS), transmission electron microscopy (TEM), Thermal gravimetric (TG), differential thermal gravimetric (DTG), N-2 adsorption-desorption isotherms (BET) and elemental analysis. MIL-100(Cr)/NHEtN(CH2PO3H2)(2) successfully applied for the synthesis of new categories of N-heterocyclic compounds such as tetrahydropyrimido[4,5-b]quinoline-2,4,6(1H,3H,7H)-trione, tetrahydropyrimido[4,5-b]quinoline-4,6(31-1,7H)-dione and octahydropyrimido[4,5-b]quinolin-6(110-one derivatives. More specifically, this paper has explored new tetrahydropyrimido[4,5-b]quinolone based on uracil (X = S, O). The major advantages of this work are high yields, short reaction times, high stability thermal, facile workup and reusability of the MOFs catalyst.