期刊
REVIEWS ON ENVIRONMENTAL HEALTH
卷 34, 期 2, 页码 197-210出版社
WALTER DE GRUYTER GMBH
DOI: 10.1515/reveh-2018-0070
关键词
insecticides; leukemia; lymphoma; permethrin; pyrethroids
资金
- CONACyT [CB-2012-01-183467]
- National Pediatrics Institute
- National Council of Science and Technology (CONACyT) [CVU 385279]
- UNAM
Pyrethroid insecticides are commonly used worldwide. The chronic effects of these compounds are of concern given that epidemiological studies have suggested an association with hematological cancer, particularly in children. However, the biological evidence at molecular and cellular levels is limited. A review on the molecular and cellular effects of pyrethroids is helpful to guide the study of the biological plausibility of the association of pyrethroids with hematological cancer. We reviewed studies suggesting that pyrethroids are genotoxic, induce genetic rearrangements, alter gene expression and modify DNA. All of these biological modifications could potentially contribute to the carcinogenic process in hematopoietic cells.
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