相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Discovery of the Cyclic Lipopeptide Gacamide A by Genome Mining and Repair of the Defective GacA Regulator in Pseudomonas fluorescens Pf0-1
Gahzaleh Jahanshah et al.
JOURNAL OF NATURAL PRODUCTS (2019)
Triggering the expression of a silent gene cluster from genetically intractable bacteria results in scleric acid discovery
Fabrizio Alberti et al.
CHEMICAL SCIENCE (2019)
Rare taxa and dark microbial matter: novel bioactive actinobacteria abound in Atacama Desert soils
Michael Goodfellow et al.
ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY (2018)
Identification and heterologous expression of the actinoallolide biosynthetic gene cluster
Yuki Inahashi et al.
JOURNAL OF ANTIBIOTICS (2018)
Hybrid MS/NMR methods on the prioritization of natural products: Applications in drug discovery
Nelson G. M. Gomes et al.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2018)
Design, development and application of whole-cell based antibiotic-specific biosensor
Yuriy Reberts et al.
METABOLIC ENGINEERING (2018)
Heterologous expression and antitumor activity analysis of syringolin from &ITPseudomonas syringae &ITpv. &ITsyringae &ITB728a
Fan Huang et al.
MICROBIAL CELL FACTORIES (2018)
Characterization and heterologous expression of the neoabyssomicin/abyssomicin biosynthetic gene cluster from Streptomyces koyangensis SCSIO 5802
Jiajia Tu et al.
MICROBIAL CELL FACTORIES (2018)
Discovery, Biosynthesis, and Heterologous Production of Streptoseomycin, an Anti-Microaerophilic Bacteria Macrodilactone
Bo Zhang et al.
ORGANIC LETTERS (2018)
Self-resistance guided genome mining uncovers new topoisomerase inhibitors from myxobacteria
Fabian Panter et al.
CHEMICAL SCIENCE (2018)
A standardized workflow for submitting data to the Minimum Information about a Biosynthetic Gene cluster (MIBiG) repository: prospects for research-based educational experiences
Samuel C. Epstein et al.
STANDARDS IN GENOMIC SCIENCES (2018)
Bioprospecting Deep-Sea Actinobacteria for Novel Anti-infective Natural Products
Dongbo Xu et al.
FRONTIERS IN MICROBIOLOGY (2018)
Genomics-Based Insights Into the Biosynthesis and Unusually High Accumulation of Free Fatty Acids by Streptomyces sp NP10
Olha Schneider et al.
FRONTIERS IN MICROBIOLOGY (2018)
High-Yield Production of Herbicidal Thaxtomins and Thaxtomin Analogs in a Nonpathogenic Streptomyces Strain
Guangde Jiang et al.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2018)
Generation of a cluster-free Streptomyces albus chassis strains for improved heterologous expression of secondary metabolite clusters
Maksym Myronovskyi et al.
METABOLIC ENGINEERING (2018)
Genome Mining of Streptomyces sp. YIM 130001 Isolated From Lichen Affords New Thiopeptide Antibiotic
Olha Schneider et al.
FRONTIERS IN MICROBIOLOGY (2018)
Crocadepsins-Depsipeptides from the Myxobacterium Chondromyces crocatus Found by a Genome Mining Approach
Frank Surup et al.
ACS CHEMICAL BIOLOGY (2018)
Increased heterologous production of the antitumoral polyketide mithramycin A by engineered Streptomyces lividans TK24 strains
Renata Novakova et al.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2018)
Concepts and Methods to Access Novel Antibiotics from Actinomycetes
Joachim J. Hug et al.
ANTIBIOTICS-BASEL (2018)
PCR-Independent Method of Transformation-Associated Recombination Reveals the Cosmomycin Biosynthetic Gene Cluster in an Ocean Streptomycete
Charles B. Larson et al.
JOURNAL OF NATURAL PRODUCTS (2017)
Identification and heterologous expression of the kocurin biosynthetic gene cluster
Luis Linares-Otoya et al.
MICROBIOLOGY-SGM (2017)
Comparative mass spectrometry-based metabolomics strategies for the investigation of microbial secondary metabolites
Brett C. Covington et al.
NATURAL PRODUCT REPORTS (2017)
Minimum information about a single amplified genome (MISAG) and a metagenome-assembled genome (MIMAG) of bacteria and archaea
Robert M. Bowers et al.
NATURE BIOTECHNOLOGY (2017)
CRISPR-Cas9 strategy for activation of silent Streptomyces biosynthetic gene clusters
Mingzi M. Zhang et al.
NATURE CHEMICAL BIOLOGY (2017)
Development of a Biosensor Concept to Detect the Production of Cluster-Specific Secondary Metabolites
Yi-Qian Sun et al.
ACS SYNTHETIC BIOLOGY (2017)
Identification by Genome Mining of a Type I Polyketide Gene Cluster from Streptomyces argillaceus Involved in the Biosynthesis of Pyridine and Piperidine Alkaloids Argimycins P
Suhui Ye et al.
FRONTIERS IN MICROBIOLOGY (2017)
Actinoalloteichus fjordicus sp nov isolated from marine sponges: phenotypic, chemotaxonomic and genomic characterisation
Imen Nouioui et al.
ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY (2017)
Chemical ecology of antibiotic production by actinomycetes
Anne Van der Meij et al.
FEMS MICROBIOLOGY REVIEWS (2017)
Heterologous expression of Avermectins biosynthetic gene cluster by construction of a Bacterial Artificial Chromosome library of the producers
Qian Deng et al.
SYNTHETIC AND SYSTEMS BIOTECHNOLOGY (2017)
Antibiotics and evolution: food for thought
C. R. Strachan et al.
JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY (2016)
Marizomib irreversibly inhibits proteasome to overcome compensatory hyperactivation in multiple myeloma and solid tumour patients
Nancy Levin et al.
BRITISH JOURNAL OF HAEMATOLOGY (2016)
Natural Products as Sources of New Drugs from 1981 to 2014
David J. Newman et al.
JOURNAL OF NATURAL PRODUCTS (2016)
Biosynthetic engineering of nonribosomal peptide synthetases
Hajo Kries
JOURNAL OF PEPTIDE SCIENCE (2016)
Dual control system - A novel scaffolding architecture of an inducible regulatory device for the precise regulation of gene expression
L. Horbal et al.
METABOLIC ENGINEERING (2016)
Activation of a plasmid-situated type III PKS gene cluster by deletion of a wbl gene in deepsea-derived Streptomyces somaliensis SCSIO ZH66
Huiming Huang et al.
MICROBIAL CELL FACTORIES (2016)
New tools for reconstruction and heterologous expression of natural product biosynthetic gene clusters
Yunzi Luo et al.
NATURAL PRODUCT REPORTS (2016)
Genetic engineering of modular PKSs: from combinatorial biosynthesis to synthetic biology
Kira J. Weissman
NATURAL PRODUCT REPORTS (2016)
Human commensals producing a novel antibiotic impair pathogen colonization
Alexander Zipperer et al.
NATURE (2016)
CasHRA (Cas9-facilitated Homologous Recombination Assembly) method of constructing megabase-sized DNA
Jianting Zhou et al.
NUCLEIC ACIDS RESEARCH (2016)
Cloning and Heterologous Expression of the Grecocycline Biosynthetic Gene Cluster
Oksana Bilyk et al.
PLOS ONE (2016)
Genomic charting of ribosomally synthesized natural product chemical space facilitates targeted mining
Michael A. Skinnider et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
One-step high-efficiency CRISPR/Cas9-mediated genome editing in Streptomyces
He Huang et al.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA (2015)
Pseudomycoicidin, a Class II Lantibiotic from Bacillus pseudomycoides
Shradha Basi-Chipalu et al.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2015)
Highly efficient editing of the actinorhodin polyketide chain length factor gene in Streptomyces coelicolor M145 using CRISPR/Cas9-CodA(sm) combined system
Hu Zeng et al.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2015)
Structural diversity and possible functional roles of free fatty acids of the novel soil isolate Streptomyces sp NP10
Tatjana Ilic-Tomic et al.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2015)
CRISPR/Cas9 nuclease cleavage combined with Gibson assembly for seamless cloning
Jia-Wang Wang et al.
BIOTECHNIQUES (2015)
Identification and analysis of the bacterial endosymbiont specialized for production of the chemotherapeutic natural product ET-743
Michael M. Schofield et al.
ENVIRONMENTAL MICROBIOLOGY (2015)
Application of iChip to Grow Uncultivable Microorganisms and its Impact on Antibiotic Discovery
Rinzhin T. Sherpa et al.
JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES (2015)
A new antibiotic kills pathogens without detectable resistance
Losee L. Ling et al.
NATURE (2015)
An enzyme-coupled biosensor enables (S)-reticuline production in yeast from glucose
William C. DeLoache et al.
NATURE CHEMICAL BIOLOGY (2015)
antiSMASH 3.0-a comprehensive resource for the genome mining of biosynthetic gene clusters
Tilmann Weber et al.
NUCLEIC ACIDS RESEARCH (2015)
Dynamic signal processing by ribozyme-mediated RNA circuits to control gene expression
Shensi Shen et al.
NUCLEIC ACIDS RESEARCH (2015)
Expanding the Chemical Diversity of the Antitumoral Compound Mithramycin by Combinatorial Biosynthesis and Biocatalysis: The Quest for Mithralogs with Improved Therapeutic Window
Carmen Méndez et al.
PLANTA MEDICA (2015)
In Vitro CRISPR/Cas9 System for Efficient Targeted DNA Editing
Yunkun Liu et al.
MBIO (2015)
Cas9-Assisted Targeting of CHromosome segments CATCH enables one-step targeted cloning of large gene clusters
Wenjun Jiang et al.
NATURE COMMUNICATIONS (2015)
Directed natural product biosynthesis gene cluster capture and expression in the model bacterium Bacillus subtilis
Yongxin Li et al.
SCIENTIFIC REPORTS (2015)
Genome Mining-Directed Activation of a Silent Angucycline Biosynthetic Gene Cluster in Streptomyces chattanoogensis
Zhenxing Zhou et al.
CHEMBIOCHEM (2015)
Direct Capture and Heterologous Expression of Salinispora Natural Product Genes for the Biosynthesis of Enterocin
Bailey Bonet et al.
JOURNAL OF NATURAL PRODUCTS (2015)
Targeted Capture and Heterologous Expression of the Pseudoalteromonas Alterochromide Gene Cluster in Escherichia coil Represents a Promising Natural Product Exploratory Platform
Avena C. Ross et al.
ACS SYNTHETIC BIOLOGY (2015)
High-Efficiency Multiplex Genome Editing of Streptomyces Species Using an Engineered CRISPR/Cas System
Ryan E. Cobb et al.
ACS SYNTHETIC BIOLOGY (2015)
A Streptomyces coelicolor host for the heterologous expression of Type III polyketide synthase genes
Anyarat Thanapipatsiri et al.
MICROBIAL CELL FACTORIES (2015)
Discovery of Clostrubin, an Exceptional Polyphenolic Polyketide Antibiotic from a Strictly Anaerobic Bacterium
Sacha Pidot et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2014)
A Systematic Analysis of Biosynthetic Gene Clusters in the Human Microbiome Reveals a Common Family of Antibiotics
Mohamed S. Donia et al.
CELL (2014)
Mining the Metabiome: Identifying Novel Natural Products from Microbial Communities
Aleksandr Milshteyn et al.
CHEMISTRY & BIOLOGY (2014)
Principles of genetic circuit design
Jennifer A. N. Brophy et al.
NATURE METHODS (2014)
Heterologous Expression of the Thiopeptide Antibiotic GE2270 from Planobispora rosea ATCC 53733 in Streptomyces coelicolor Requires Deletion of Ribosomal Genes from the Expression Construct
Katrin Flinspach et al.
PLOS ONE (2014)
Genomics of Sponge-Associated Streptomyces spp. Closely Related to Streptomyces albus J1074: Insights into Marine Adaptation and Secondary Metabolite Biosynthesis Potential
Elena Ian et al.
PLOS ONE (2014)
Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A
Kazuya Yamanaka et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Diversity and evolution of secondary metabolism in the marine actinomycete genus Salinispora
Nadine Ziemert et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Activation and identification of five clusters for secondary metabolites in Streptomyces albus J1074
Carlos Olano et al.
MICROBIAL BIOTECHNOLOGY (2014)
A Decade of Riboswitches
Alexander Serganov et al.
CELL (2013)
Seven Ways to Preserve the Miracle of Antibiotics
John G. Bartlett et al.
CLINICAL INFECTIOUS DISEASES (2013)
Diversity and isolation of rare actinomycetes: an overview
Kavita Tiwari et al.
CRITICAL REVIEWS IN MICROBIOLOGY (2013)
Cloning, Characterization and Heterologous Expression of the Indolocarbazole Biosynthetic Gene Cluster from Marine-Derived Streptomyces sanyensis FMA
Tong Li et al.
MARINE DRUGS (2013)
Molecular Regulation of Antibiotic Biosynthesis in Streptomyces
Gang Liu et al.
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS (2013)
BAGEL3: automated identification of genes encoding bacteriocins and (non-)bactericidal posttranslationally modified peptides
Auke J. van Heel et al.
NUCLEIC ACIDS RESEARCH (2013)
Discovery of indolotryptoline antiproliferative agents by homology-guided metagenomic screening
Fang-Yuan Chang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
The posttranslational modification cascade to the thiopeptide berninamycin generates linear forms and altered macrocyclic scaffolds
Steven J. Malcolmson et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Activation and characterization of a cryptic polycyclic tetramate macrolactam biosynthetic gene cluster
Yunzi Luo et al.
NATURE COMMUNICATIONS (2013)
Engineered Streptomyces avermitilis Host for Heterologous Expression of Biosynthetic Gene Cluster for Secondary Metabolites
Mamoru Komatsu et al.
ACS SYNTHETIC BIOLOGY (2013)
A Novel Mithramycin Analogue with High Antitumor Activity and Less Toxicity Generated by Combinatorial Biosynthesis
Luz E. Nunez et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Tetarimycin A, an MRSA-Active Antibiotic Identified through Induced Expression of Environmental DNA Gene Clusters
Dimitris Kallifidas et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)
Synthetic biology and the development of tools for metabolic engineering
Jay D. Keasling
METABOLIC ENGINEERING (2012)
Are Uncultivated Bacteria Really Uncultivable?
Indun Dewi Puspita et al.
MICROBES AND ENVIRONMENTS (2012)
Genome streamlining and chemical defense in a coral reef symbiosis
Jason C. Kwan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Structure and biosynthesis of the unusual polyketide alkaloid coelimycin P1, a metabolic product of the cpk gene cluster of Streptomyces coelicolor M145
Juan Pablo Gomez-Escribano et al.
CHEMICAL SCIENCE (2012)
Exploitation of phage battery in the search for bioactive actinomycetes
D. Ipek Kurtboeke
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2011)
Polyketide synthase pathways identified from a metagenomic library are derived from soil Acidobacteria
Larissa C. Parsley et al.
FEMS MICROBIOLOGY ECOLOGY (2011)
Proposals Seek to Reduce Resistance, Boost Development of New Antibiotics
Bridget M. Kuehn
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2011)
Exploiting plug-and-play synthetic biology for drug discovery and production in microorganisms
Marnix H. Medema et al.
NATURE REVIEWS MICROBIOLOGY (2011)
Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens
Luisa Laureti et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Engineering Streptomyces coelicolor for heterologous expression of secondary metabolite gene clusters
Juan Pablo Gomez-Escribano et al.
MICROBIAL BIOTECHNOLOGY (2011)
Genetically Engineered Lipopeptide Antibiotics Related to A54145 and Daptomycin with Improved Properties
Kien T. Nguyen et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2010)
Sequence-Based Analysis of Secondary-Metabolite Biosynthesis in Marine Actinobacteria
Erin A. Gontang et al.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2010)
Cloning Large Natural Product Gene Clusters from the Environment: Piecing Environmental DNA Gene Clusters Back Together with TAR
Jeffrey H. Kim et al.
BIOPOLYMERS (2010)
Heterologous Expression of the Biosynthetic Gene Clusters of Coumermycin A1, Clorobiocin and Caprazamycins in Genetically Modified Streptomyces coelicolor Strains
Katrin Flinspach et al.
BIOPOLYMERS (2010)
Deletion of a regulatory gene within the cpk gene cluster reveals novel antibacterial activity in Streptomyces coelicolor A3(2)
Marco Gottelt et al.
MICROBIOLOGY-SGM (2010)
Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism
Mamoru Komatsua et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Production of the Novel Two-Peptide Lantibiotic Lichenicidin by Bacillus licheniformis DSM 13
Jasmin Dischinger et al.
PLOS ONE (2009)
Improved Antifungal Polyene Macrolides via Engineering of the Nystatin Biosynthetic Genes in Streptomyces noursei
Trygve Brautaset et al.
CHEMISTRY & BIOLOGY (2008)
Mithramycin analogues generated by combinatorial biosynthesis show improved bioactivity
Irfan Baig et al.
JOURNAL OF NATURAL PRODUCTS (2008)
Non-ribosomal peptide synthetase module fusions to produce derivatives of daptomycin in Streptomyces roseosporus
Sascha Doekel et al.
MICROBIOLOGY-SGM (2008)
Construction of soil environmental DNA cosmid libraries and screening for clones that produce biologically active small molecules
Sean F. Brady
NATURE PROTOCOLS (2007)
Discovery of a new peptide natural product by Streptomyces coelicolor genome mining
S Lautru et al.
NATURE CHEMICAL BIOLOGY (2005)
Salinispora arenicola gen. nov., sp nov and Salinispora tropica sp nov., obligate marine actinomycetes belonging to the family Micromonosporaceae
LA Maldonado et al.
INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY (2005)
Heterologous expression of novobiocin and clorobiocin biosynthetic gene clusters
AS Eustáquio et al.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2005)
Polyketide biosynthesis: understanding and exploiting modularity
KJ Weissman
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES (2004)
lambda red-mediated genetic manipulation of antibiotic-producing Streptomyces
B Gust et al.
ADVANCES IN APPLIED MICROBIOLOGY, VOL 54 (2004)
Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK:: Three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis
LL Remsing et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2003)
Isolation of antibiotics turbomycin A and B from a metagenomic library of soil microbial DNA
DE Gillespie et al.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2002)
Evidence for the biosynthesis of bryostatins by the bacterial symbiont Candidatus Endobugula sertula of the bryozoan Bugula neritina
SK Davidson et al.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2001)
Biosynthesis of the polyene antifungal antibiotic nystatin in Streptomyces noursei ATCC 11455:: analysis of the gene cluster and deduction of the biosynthetic pathway
T Brautaset et al.
CHEMISTRY & BIOLOGY (2000)
Biosynthesis of the lantibiotic mersacidin: Organization of a type B lantibiotic gene cluster
K Altena et al.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2000)