期刊
CELLS
卷 8, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/cells8020147
关键词
Hedgehog signaling; Gli proteins; posttranslational modifications; primary cilia; cancer; developmental signaling; morphogen signaling; nuclear import
类别
资金
- Narodowe Centrum Nauki grants SONATA BIS [2014/14/E/NZ3/00033]
- FUGA [2016/20/S/NZ3/00213, PRELUDIUM 2018/29/N/NZ3/01523]
Gli proteins are transcriptional effectors of the Hedgehog signaling pathway. They play key roles in the development of many organs and tissues, and are deregulated in birth defects and cancer. We review the molecular mechanisms of Gli protein regulation in mammals, with special emphasis on posttranslational modifications and intracellular transport. We also discuss how Gli proteins interact with co-activators and co-repressors to fine-tune the expression of Hedgehog target genes. Finally, we provide an overview of the regulation of developmental processes and tissue regeneration by Gli proteins and discuss how these proteins are involved in cancer progression, both through canonical regulation via the Hedgehog pathway and through cross-talk with other signaling pathways.
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