期刊
CELLS
卷 8, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/cells8020100
关键词
mitochondrial DNA; base excision repair; metabolic syndrome; neurodegenerative diseases; aging
类别
资金
- NIH [DK100640]
As the primary cellular location for respiration and energy production, mitochondria serve in a critical capacity to the cell. Yet, by virtue of this very function of respiration, mitochondria are subject to constant oxidative stress that can damage one of the unique features of this organelle, its distinct genome. Damage to mitochondrial DNA (mtDNA) and loss of mitochondrial genome integrity is increasingly understood to play a role in the development of both severe early-onset maladies and chronic age-related diseases. In this article, we review the processes by which mtDNA integrity is maintained, with an emphasis on the repair of oxidative DNA lesions, and the cellular consequences of diminished mitochondrial genome stability.
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