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CELL DEATH & DISEASE (2017)
Dendrogenin A drives LXR to trigger lethal autophagy in cancers
Gregory Segala et al.
NATURE COMMUNICATIONS (2017)
Chemotherapy-Resistant Human Acute Myeloid Leukemia Cells Are Not Enriched for Leukemic Stem Cells but Require Oxidative Metabolism
Thomas Farge et al.
CANCER DISCOVERY (2017)
Identification of a cytogenetic and molecular subgroup of acute myeloid leukemias showing sensitivity to L-Asparaginase
Salvatore Nicola Bertuccio et al.
ONCOTARGET (2017)
Monocarboxylate transporter 1 (MCT1), a tool to stratify acute myeloid leukemia (AML) patients and a vehicle to kill cancer cells
Filipa Lopes-Coelho et al.
ONCOTARGET (2017)
Voruciclib, a clinical stage oral CDK9 inhibitor, represses MCL-1 and sensitizes high-risk Diffuse Large B-cell Lymphoma to BCL2 inhibition
Joyoti Dey et al.
SCIENTIFIC REPORTS (2017)
Vosaroxin in combination with decitabine in newly diagnosed older patients with acute myeloid leukemia or high-risk myelodysplastic syndrome
Naval Daver et al.
HAEMATOLOGICA (2017)
A Phase II Study of Arginine Deiminase (ADI-PEG20) in Relapsed/Refractory or Poor-Risk Acute Myeloid Leukemia Patients
Hui-Jen Tsai et al.
SCIENTIFIC REPORTS (2017)
Prognostic significance of alterations of pathways regulating autophagy in acute myeloid leukemia.
Giovanni Marconi et al.
JOURNAL OF CLINICAL ONCOLOGY (2017)
Inhibition of Mcl-1 enhances cell death induced by the Bcl-2-selective inhibitor ABT-199 in acute myeloid leukemia cells
Daniel A. Luedtke et al.
SIGNAL TRANSDUCTION AND TARGETED THERAPY (2017)
Gene expression and risk of leukemic transformation in myelodysplasia
Yusuke Shiozawa et al.
BLOOD (2017)
Synthetic Lethality of Combined Bcl-2 Inhibition and p53 Activation in AML: Mechanisms and Superior Antileukemic Efficacy
Rongqing Pan et al.
CANCER CELL (2017)
Direct Activation of BAX by BTSA1 Overcomes Apoptosis Resistance in Acute Myeloid Leukemia
Denis E. Reyna et al.
CANCER CELL (2017)
Emerging therapies for acute myeloid leukemia: translating biology into the clinic
Simon Kavanagh et al.
JCI INSIGHT (2017)
Acute myeloid leukaemia genomics
Michael Medinger et al.
BRITISH JOURNAL OF HAEMATOLOGY (2017)
NADPH oxidase-2 derived superoxide drives mitochondrial transfer from bone marrow stromal cells to leukemic blasts
Christopher R. Marlein et al.
BLOOD (2017)
Therapy-Related Clonal Hematopoiesis in Patients with Non-hematologic Cancers Is Common and Associated with Adverse Clinical Outcomes
Catherine C. Coombs et al.
CELL STEM CELL (2017)
Putting p53 in Context
Edward R. Kastenhuber et al.
CELL (2017)
Co-occurrence of FLT3-TKD and NPM1 mutations defines a highly favorable prognostic AML group
Prajwal Boddu et al.
BLOOD ADVANCES (2017)
Correlation Between Isocitrate Dehydrogenase Gene Aberrations and Prognosis of Patients with Acute Myeloid Leukemia: A Systematic Review and Meta-Analysis
Qingyu Xu et al.
CLINICAL CANCER RESEARCH (2017)
Mitochondrial BAX Determines the Predisposition to Apoptosis in Human AML
Frank Reichenbach et al.
CLINICAL CANCER RESEARCH (2017)
Dysfunctional diversity of p53 proteins in adult acute myeloid leukemia: projections on diagnostic workup and therapy
Miron Prokocimer et al.
BLOOD (2017)
Enasidenib in mutant IDH2 relapsed or refractory acute myeloid leukemia
Eytan M. Stein et al.
BLOOD (2017)
Ultra-sensitive Sequencing Identifies High Prevalence of Clonal Hematopoiesis-Associated Mutations throughout Adult Life
Rocio Acuna-Hidalgo et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2017)
Heterogeneous resistance to quizartinib in acute myeloid leukemia revealed by single-cell analysis
Catherine C. Smith et al.
BLOOD (2017)
Mitochondrial Dynamics in Regulating the Unique Phenotypes of Cancer and Stem Cells
Hsiuchen Chen et al.
CELL METABOLISM (2017)
Preclinical evaluation of AMG 176, a novel, potent and selective Mcl-1 inhibitor with robust anti-tumor activity in Mcl-1 dependent cancer models
Sean R. Caenepeel et al.
CANCER RESEARCH (2017)
ABBV-621: A best-in-class TRAIL-receptor agonist fusion protein that enhances optimal clustering for the treatment of solid and hematologic tumors
Susan E. Morgan-Lappe
CANCER RESEARCH (2017)
AZD5991: A potent and selective macrocyclic inhibitor of Mcl-1 for treatment of hematologic cancers
Alexander W. Hird et al.
CANCER RESEARCH (2017)
Exploring the TRAILs less travelled: TRAIL in cancer biology and therapy
Silvia von Karstedt et al.
NATURE REVIEWS CANCER (2017)
PU.1 supports TRAIL-induced cell death by inhibiting NF-κB-mediated cell survival and inducing DR5 expression
Aladin Haimovici et al.
CELL DEATH AND DIFFERENTIATION (2017)
Leveraging increased cytoplasmic nucleoside kinase activity to target mtDNA and oxidative phosphorylation in AML
Sanduni U. Liyanage et al.
BLOOD (2017)
Bone Marrow Adipocytes Facilitate Fatty Acid Oxidation Activating AMPK and a Transcriptional Network Supporting Survival of Acute Monocytic Leukemia Cells
Yoko Tabe et al.
CANCER RESEARCH (2017)
Marker chromosomes can arise from chromothripsis and predict adverse prognosis in acute myeloid leukemia
Tilmann Bochtler et al.
BLOOD (2017)
N-glycosylation of mouse TRAIL-R and human TRAIL-R1 enhances TRAIL-induced death
Florent Dufour et al.
CELL DEATH AND DIFFERENTIATION (2017)
Understanding the Intersections between Metabolism and Cancer Biology
Matthew G. Vander Heiden et al.
CELL (2017)
BCL-2: Long and winding path from discovery to therapeutic target
Robyn L. Schenk et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)
The CDK9 Inhibitor Dinaciclib Exerts Potent Apoptotic and Antitumor Effects in Preclinical Models of MLL-Rearranged Acute Myeloid Leukemia
Adele Baker et al.
CANCER RESEARCH (2016)
Fumarate and Succinate Regulate Expression of Hypoxia-inducible Genes via TET Enzymes
Tuomas Laukka et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2016)
Somatic mutational landscape of AML with inv(16) or t(8;21) identifies patterns of clonal evolution in relapse leukemia
R. Sood et al.
LEUKEMIA (2016)
Blockade of BCL-2 proteins efficiently induces apoptosis in progenitor cells of high-risk myelodysplastic syndromes patients
S. Jilg et al.
LEUKEMIA (2016)
iBH3: simple, fixable BH3 profiling to determine apoptotic priming in primary tissue by flow cytometry
Jeremy Ryan et al.
BIOLOGICAL CHEMISTRY (2016)
Targeting FLT3-ITD signaling mediates ceramide-dependent mitophagy and attenuates drug resistance in AML
Mohammed Dany et al.
BLOOD (2016)
Atg7 suppression enhances chemotherapeutic agent sensitivity and overcomes stroma-mediated chemoresistance in acute myeloid leukemia
Sujan Piya et al.
BLOOD (2016)
Evolution of acute myelogenous leukemia stem cell properties after treatment and progression
Tzu-Chieh Ho et al.
BLOOD (2016)
Spectrum and prognostic relevance of driver gene mutations in acute myeloid leukemia
Klaus H. Metzeler et al.
BLOOD (2016)
TP53 mutations in newly diagnosed acute myeloid leukemia: Clinicomolecular characteristics, response to therapy, and outcomes
Tapan M. Kadia et al.
CANCER (2016)
Enhanced Fructose Utilization Mediated by SLC2A5 Is a Unique Metabolic Feature of Acute Myeloid Leukemia with Therapeutic Potential
Wen-Lian Chen et al.
CANCER CELL (2016)
Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia
David B. Sykes et al.
CELL (2016)
The Autophagy Machinery Controls Cell Death Switching between Apoptosis and Necroptosis
Megan L. Goodall et al.
DEVELOPMENTAL CELL (2016)
Oxidative stress and hypoxia in normal and leukemic stem cells
Ugo Testa et al.
EXPERIMENTAL HEMATOLOGY (2016)
Functionally identifiable apoptosis-insensitive subpopulations determine chemoresistance in acute myeloid leukemia
Patrick D. Bhola et al.
JOURNAL OF CLINICAL INVESTIGATION (2016)
Genetically distinct leukemic stem cells in human CD34- acute myeloid leukemia are arrested at a hemopoietic precursor-like stage
Lynn Quek et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2016)
CXCL12 promotes glycolytic reprogramming in acute myeloid leukemia cells via the CXCR4/mTOR axis
M. Braun et al.
LEUKEMIA (2016)
PHD3 Loss in Cancer Enables Metabolic Reliance on Fatty Acid Oxidation via Deactivation of ACC2
Natalie J. German et al.
MOLECULAR CELL (2016)
Co-operative and Hierarchical Binding of c-FLIP and Caspase-8: A Unified Model Defines How c-FLIP Isoforms Differentially Control Cell Fate
Michelle A. Hughes et al.
MOLECULAR CELL (2016)
Cryo-EM Structure of Caspase-8 Tandem DED Filament Reveals Assembly and Regulation Mechanisms of the Death-Inducing Signaling Complex
Tian-Min Fu et al.
MOLECULAR CELL (2016)
Mitochondria-Judges and Executioners of Cell Death Sentences
Patrick D. Bhola et al.
MOLECULAR CELL (2016)
Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition
Marco Sciacovelli et al.
NATURE (2016)
The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models
Andras Kotschy et al.
NATURE (2016)
A 17-gene stemness score for rapid determination of risk in acute leukaemia
Stanley W. K. Ng et al.
NATURE (2016)
The genomic landscape of core-binding factor acute myeloid leukemias
Zachary J. Faber et al.
NATURE GENETICS (2016)
Assessment of Minimal Residual Disease in Standard-Risk AML
A. Ivey et al.
NEW ENGLAND JOURNAL OF MEDICINE (2016)
TP53 and Decitabine in Acute Myeloid Leukemia and Myelodysplastic Syndromes
J. S. Welch et al.
NEW ENGLAND JOURNAL OF MEDICINE (2016)
Genomic Classification and Prognosis in Acute Myeloid Leukemia
Elli Papaemmanuil et al.
NEW ENGLAND JOURNAL OF MEDICINE (2016)
ATM/G6PD-driven redox metabolism promotes FLT3 inhibitor resistance in acute myeloid leukemia
Mark A. Gregory et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
ONC201 kills solid tumor cells by triggering an integrated stress response dependent on ATF4 activation by specific eIF2α kinases
C. Leah B. Kline et al.
SCIENCE SIGNALING (2016)
ATF4 induction through an atypical integrated stress response to ONC201 triggers p53-independent apoptosis in hematological malignancies
Jo Ishizawa et al.
SCIENCE SIGNALING (2016)
The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia
Gabriela Brumatti et al.
SCIENCE TRANSLATIONAL MEDICINE (2016)
Development of ML390: A Human DHODH Inhibitor That Induces Differentiation in Acute Myeloid Leukemia
Timothy A. Lewis et al.
ACS MEDICINAL CHEMISTRY LETTERS (2016)
ZBTB7A mutations in acute myeloid leukaemia with t(8;21) translocation
Luise Hartmann et al.
NATURE COMMUNICATIONS (2016)
Efficacy and Biological Correlates of Response in a Phase II Study of Venetoclax Monotherapy in Patients with Acute Myelogenous Leukemia
Marina Konopleva et al.
CANCER DISCOVERY (2016)
Smac mimetic induces cell death in a large proportion of primary acute myeloid leukemia samples, which correlates with defined molecular markers
Sonja C. Lueck et al.
ONCOTARGET (2016)
Discovery and clinical introduction of first-in-class imipridone ONC201
Joshua E. Allen et al.
ONCOTARGET (2016)
Inhibiting glutaminase in acute myeloid leukemia: metabolic dependency of selected AML subtypes
Polina Matre et al.
ONCOTARGET (2016)
ONC201 kills solid tumor cells by triggering an integrated stress response dependent on ATF4 activation by specific eIF2α kinases
C. Leah B. Kline et al.
SCIENCE SIGNALING (2016)
ATF4 induction through an atypical integrated stress response to ONC201 triggers p53-independent apoptosis in hematological malignancies
Jo Ishizawa et al.
SCIENCE SIGNALING (2016)
High Expression of CPT1A Predicts Adverse Outcomes: A Potential Therapeutic Target for Acute Myeloid Leukemia
Jinlong Shi et al.
EBIOMEDICINE (2016)
Dynamic BH3 profiling-poking cancer cells with a stick
Joan Montero et al.
MOLECULAR & CELLULAR ONCOLOGY (2016)
Arginine dependence of acute myeloid leukemia blast proliferation: a novel therapeutic target
Francis Mussai et al.
BLOOD (2015)
Targeting the leukemia cell metabolism by the CPT1a inhibition: functional preclinical effects in leukemias
Maria Rosaria Ricciardi et al.
BLOOD (2015)
International phase 3 study of azacitidine vs conventional care regimens in older patients with newly diagnosed AML with >30% blasts
Herve Dombret et al.
BLOOD (2015)
Targeting glutaminolysis has antileukemic activity in acute myeloid leukemia and synergizes with BCL-2 inhibition
Nathalie Jacque et al.
BLOOD (2015)
Arginine deprivation using pegylated arginine deiminase has activity against primary acute myeloid leukemia cells in vivo
Farideh Miraki-Moud et al.
BLOOD (2015)
Drug-Induced Death Signaling Strategy Rapidly Predicts Cancer Response to Chemotherapy
Joan Montero et al.
CELL (2015)
The BCL-2 protein family, BH3-mimetics and cancer therapy
A. R. D. Delbridge et al.
CELL DEATH AND DIFFERENTIATION (2015)
AMPK Protects Leukemia-Initiating Cells in Myeloid Leukemias from Metabolic Stress in the Bone Marrow
Yusuke Saito et al.
CELL STEM CELL (2015)
Negative regulation of the LKB1/AMPK pathway by ERK in human acute myeloid leukemia cells
Ichiro Kawashima et al.
EXPERIMENTAL HEMATOLOGY (2015)
Randomized multicenter phase II study of flavopiridol (alvocidib), cytarabine, and mitoxantrone (FLAM) versus cytarabine/daunorubicin (7+3) in newly diagnosed acute myeloid leukemia
Joshua F. Zeidner et al.
HAEMATOLOGICA (2015)
Identification of TRAIL-inducing compounds highlights small molecule ONC201/TIC10 as a unique anti-cancer agent that activates the TRAIL pathway
Joshua E. Allen et al.
MOLECULAR CANCER (2015)
Lenalidomide induces ubiquitination and degradation of CK1a in del(5q) MDS
Jan Kroenke et al.
NATURE (2015)
Isocitrate dehydrogenase 1 and 2 mutations induce BCL-2 dependence in acute myeloid leukemia
Steven M. Chan et al.
NATURE MEDICINE (2015)
Acute Myeloid Leukemia
Hartmut Doehner et al.
NEW ENGLAND JOURNAL OF MEDICINE (2015)
Single-cell genotyping demonstrates complex clonal diversity in acute myeloid leukemia
Amy L. Paguirigan et al.
SCIENCE TRANSLATIONAL MEDICINE (2015)
Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax)
J. D. Leverson et al.
CELL DEATH & DISEASE (2015)
TP53 mutations in de novo acute myeloid leukemia patients: longitudinal follow-ups show the mutation is stable during disease evolution
H-A Hou et al.
BLOOD CANCER JOURNAL (2015)
Co-activation of AMPK and mTORC1 Induces Cytotoxicity in Acute Myeloid Leukemia
Pierre Sujobert et al.
CELL REPORTS (2015)
Randomized multicenter phase II study of flavopiridol (alvocidib), cytarabine, and mitoxantrone (FLAM) versus cytarabine/daunorubicin (7+3) in newly diagnosed acute myeloid leukemia
Joshua F. Zeidner et al.
HAEMATOLOGICA (2015)
Acute myeloid leukemia ontogeny is defined by distinct somatic mutations
R. Coleman Lindsley et al.
BLOOD (2015)
Embelin Sensitizes Acute Myeloid Leukemia Cells to TRAIL through XIAP Inhibition and NF-κB Inactivation
Tianxin Yang et al.
CELL BIOCHEMISTRY AND BIOPHYSICS (2015)
Role of TP53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia
Terrence N. Wong et al.
NATURE (2015)
Mitochondrial Profiling of Acute Myeloid Leukemia in the Assessment of Response to Apoptosis Modulating Drugs
Jo Ishizawa et al.
PLOS ONE (2015)
Autophagy limits proliferation and glycolytic metabolism in acute myeloid leukemia
A. S. Watson et al.
CELL DEATH DISCOVERY (2015)
The glutaminase activity of L-asparaginase is not required for anticancer activity against ASNS-negative cells
Wai Kin Chan et al.
BLOOD (2014)
A distinct glucose metabolism signature of acute myeloid leukemia with prognostic value
Wen-Lian Chen et al.
BLOOD (2014)
Maritoclax induces apoptosis in acute myeloid leukemia cells with elevated Mcl-1 expression
Kenichiro Doi et al.
CANCER BIOLOGY & THERAPY (2014)
Functional Heterogeneity of Genetically Defined Subclones in Acute Myeloid Leukemia
Jeffery M. Klco et al.
CANCER CELL (2014)
Importance of Glutamine Metabolism in Leukemia Cells by Energy Production Through TCA Cycle and by Redox Homeostasis
Mineaki Goto et al.
CANCER INVESTIGATION (2014)
Cell-State-Specific Metabolic Dependency in Hematopoiesis and Leukemogenesis
Ying-Hua Wang et al.
CELL (2014)
A Phase I Study of the First-in-Class Antimitochondrial Metabolism Agent, CPI-613, in Patients with Advanced Hematologic Malignancies
Timothy S. Pardee et al.
CLINICAL CANCER RESEARCH (2014)
Inhibition of glutaminase selectively suppresses the growth of primary acute myeloid leukemia cells with IDH mutations
Ashkan Emadi et al.
EXPERIMENTAL HEMATOLOGY (2014)
Co-inhibition of NF-κB and JNK is synergistic in TNF-expressing human AML
Andrew Volk et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2014)
A Novel Small-Molecule Inhibitor of Mcl-1 Blocks Pancreatic Cancer Growth In Vitro and In Vivo
Fardokht Abulwerdi et al.
MOLECULAR CANCER THERAPEUTICS (2014)
BCL-2 family proteins as 5-Azacytidine-sensitizing targets and determinants of response in myeloid malignancies
J. M. Bogenberger et al.
LEUKEMIA (2014)
Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia
Liran I. Shlush et al.
NATURE (2014)
Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy
Peter E. Czabotar et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)
Identification of Novel Molecular Markers for Prognosis Estimation of Acute Myeloid Leukemia: Over-Expression of PDCD7, FIS1 and Ang2 May Indicate Poor Prognosis in Pretreatment Patients with Acute Myeloid Leukemia
Yiming Tian et al.
PLOS ONE (2014)
Inhibition of mTOR-Dependent Autophagy Sensitizes Leukemic Cells to Cytarabine-Induced Apoptotic Death
Mihajlo Bosnjak et al.
PLOS ONE (2014)
Preleukemic mutations in human acute myeloid leukemia affect epigenetic regulators and persist in remission
M. Ryan Corces-Zimmerman et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Necroptosis in health and diseases
Wen Zhou et al.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2014)
XIAP inhibitors induce differentiation and impair clonogenic capacity of acute myeloid leukemia stem cells
Daniel Moreno-Martinez et al.
ONCOTARGET (2014)
Autophagy Controls the Kinetics and Extent of Mitochondrial Apoptosis by Regulating PUMA Levels
Jacqueline Thorburn et al.
CELL REPORTS (2014)
A strategically designed small molecule attacks alpha-ketoglutarate dehydrogenase in tumor cells through a redox process
Shawn D. Stuart et al.
CANCER & METABOLISM (2014)
Prognostic significance of NPM1 mutations in acute myeloid leukemia: A meta-analysis
Yanfeng Liu et al.
MOLECULAR AND CLINICAL ONCOLOGY (2014)
Acute myeloid leukemia creates an arginase-dependent immunosuppressive microenvironment
Francis Mussai et al.
BLOOD (2013)
Inhibiting glutamine uptake represents an attractive new strategy for treating acute myeloid leukemia
Lise Willems et al.
BLOOD (2013)
Overproduction of NOX-derived ROS in AML promotes proliferation and is associated with defective oxidative stress signaling
Paul S. Hole et al.
BLOOD (2013)
Wild-type and mutant p53 mediate cisplatin resistance through interaction and inhibition of active caspase-9
Jacqueline L. Y. Chee et al.
CELL CYCLE (2013)
BCL-2 Inhibition Targets Oxidative Phosphorylation and Selectively Eradicates Quiescent Human Leukemia Stem Cells
Eleni D. Lagadinou et al.
CELL STEM CELL (2013)
Genomic Landscapes and Clonality of De Novo AML
John Brewin et al.
NEW ENGLAND JOURNAL OF MEDICINE (2013)
Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia
Timothy J. Ley et al.
NEW ENGLAND JOURNAL OF MEDICINE (2013)
Dual Inactivation of Akt and ERK by TIC10 Signals Foxo3a Nuclear Translocation, TRAIL Gene Induction, and Potent Antitumor Effects
Joshua E. Allen et al.
SCIENCE TRANSLATIONAL MEDICINE (2013)
Mechanisms of Action of Bcl-2 Family Proteins
Aisha Shamas-Din et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2013)
Concomitant inhibition of DNA methyltransferase and BCL-2 protein function synergistically induce mitochondrial apoptosis in acute myelogenous leukemia cells
Twee Tsao et al.
ANNALS OF HEMATOLOGY (2012)
Relative Mitochondrial Priming of Myeloblasts and Normal HSCs Determines Chemotherapeutic Success in AML
Thanh-Trang Vo et al.
CELL (2012)
Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia
Stefan P. Glaser et al.
GENES & DEVELOPMENT (2012)
Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing
Li Ding et al.
NATURE (2012)
A PML-PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance
Keisuke Ito et al.
NATURE MEDICINE (2012)
Clonal Architecture of Secondary Acute Myeloid Leukemia
Matthew J. Walter et al.
NEW ENGLAND JOURNAL OF MEDICINE (2012)
Atg7 Modulates p53 Activity to Regulate Cell Cycle and Survival During Metabolic Stress
In Hye Lee et al.
SCIENCE (2012)
Metabolomics for mitochondrial and cancer studies
Deepak Nagrath et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2011)
Immunophenotypic features of acute myeloid leukaemia patients exhibiting high FLT3 expression not associated with mutations
Roberta Riccioni et al.
BRITISH JOURNAL OF HAEMATOLOGY (2011)
Wild-type and mutant p53 proteins interact with mitochondrial caspase-3
Amanda K. Frank et al.
CANCER BIOLOGY & THERAPY (2011)
Addition of AEG35156 XIAP Antisense Oligonucleotide in Reinduction Chemotherapy Does Not Improve Remission Rates in Patients With Primary Refractory Acute Myeloid Leukemia in a Randomized Phase II Study
Aaron D. Schimmer et al.
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA (2011)
The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance
Monika Mortensen et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2011)
High TRAIL-R3 expression on leukemic blasts is associated with poor outcome and induces apoptosis-resistance which can be overcome by targeting TRAIL-R2
M. E. D. Chamuleau et al.
LEUKEMIA RESEARCH (2011)
The LKB1/AMPK signaling pathway has tumor suppressor activity in acute myeloid leukemia through the repression of mTOR-dependent oncogenic mRNA translation
Alexa S. Green et al.
BLOOD (2010)
FIP200 is required for the cell-autonomous maintenance of fetal hematopoietic stem cells
Fei Liu et al.
BLOOD (2010)
Inhibition of Glutaminase Preferentially Slows Growth of Glioma Cells with Mutant IDH1
Meghan J. Seltzer et al.
CANCER RESEARCH (2010)
Mcl1 haploinsufficiency protects mice from Myc-induced acute myeloid leukemia
Zhifu Xiang et al.
JOURNAL OF CLINICAL INVESTIGATION (2010)
Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction
Ismael Samudio et al.
JOURNAL OF CLINICAL INVESTIGATION (2010)
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate (vol 462, pg 739, 2010)
Lenny Dang et al.
NATURE (2010)
Heightened mitochondrial priming is the basis for apoptotic hypersensitivity of CD4+ CD8+ thymocytes
Jeremy A. Ryan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Pyrimidine biosynthesis links mitochondrial respiration to the p53 pathway
Anastasia A. Khutornenko et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Phorbol ester-induced PKCε down-modulation sensitizes AML cells to TRAIL-induced apoptosis and cell differentiation
Giuliana Gobbi et al.
BLOOD (2009)
FLT3-ITD up-regulates MCL-1 to promote survival of stem cells in acute myeloid leukemia via FLT3-ITD-specific STAT5 activation
Goichi Yoshimoto et al.
BLOOD (2009)
PPARδ is a ligand-dependent negative regulator of vitamin D3-induced monocyte differentiation
Athina Lymboussaki et al.
CARCINOGENESIS (2009)
Clinical Applications of Metabolomics in Oncology: A Review
Jennifer L. Spratlin et al.
CLINICAL CANCER RESEARCH (2009)
Phase I/II Trial of AEG35156 X-Linked Inhibitor of Apoptosis Protein Antisense Oligonucleotide Combined With Idarubicin and Cytarabine in Patients With Relapsed or Primary Refractory Acute Myeloid Leukemia
Aaron D. Schimmer et al.
JOURNAL OF CLINICAL ONCOLOGY (2009)
Triptolide sensitizes AML cells to TRAIL-induced apoptosis via decrease of XIAP and p53-mediated increase of DR5
Bing Z. Carter et al.
BLOOD (2008)
Synergistic Proapoptotic Activity of Recombinant TRAIL Plus the Akt Inhibitor Perifosine in Acute Myelogenous Leukemia Cells
Pier Luigi Tazzari et al.
CANCER RESEARCH (2008)
p53 target genes Sestrin1 and Sestrin2 connect genotoxic stress and mTOR signaling
Andrei V. Budanov et al.
CELL (2008)
Involvement of protective autophagy in TRAIL resistance of apoptosis-defective tumor cells
Jie Han et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Regulation of autophagy by cytoplasmic p53
Ezgi Tasdemir et al.
NATURE CELL BIOLOGY (2008)
The multikinase inhibitor sorafenib potentiates TRAIL lethality in human leukemia cells in association with mcl-1 and cFLIPL down-regulation
Roberto R. Rosato et al.
CANCER RESEARCH (2007)
Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAIL
Klaus W. Wagner et al.
NATURE MEDICINE (2007)
Apoptosis: A review of programmed cell death
Susan Elmore
TOXICOLOGIC PATHOLOGY (2007)
Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members
Michael Certo et al.
CANCER CELL (2006)
SphK1 and SphK2, sphingosine kinase isoenzymes with opposing functions in sphingolipid metabolism
M Maceyka et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
An inhibitor of Bcl-2 family proteins induces regression of solid tumours
T Oltersdorf et al.
NATURE (2005)
Expression of IAP-family proteins in adult acute mixed lineage leukemia (AMLL)
Y Nakagawa et al.
AMERICAN JOURNAL OF HEMATOLOGY (2005)
High expression levels of X-linked inhibitor of apoptosis protein and survivin correlate with poor overall survival in childhood de Novo acute myeloid leukemia
I Tamm et al.
CLINICAL CANCER RESEARCH (2004)
Sphingosine kinase type 2 is a putative BH3-only protein that induces apoptosis
H Liu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Synthetic triterpenoids activate a pathway for apoptosis in AML cells involving downregulation of FLIP and sensitization to TRAIL
WS Suh et al.
LEUKEMIA (2003)
Stromal cells prevent apoptosis of AML cells by up-regulation of anti-apoptotic proteins
M Konopleva et al.
LEUKEMIA (2002)
In vitro susceptibility to TRAIL-induced apoptosis of acute leukemia cells in the context of TRAIL receptor gene expression and constitutive NF-κB activity
C Wuchter et al.
LEUKEMIA (2001)
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