期刊
EBIOMEDICINE
卷 41, 期 -, 页码 659-669出版社
ELSEVIER
DOI: 10.1016/j.ebiom.2019.03.003
关键词
Spinal cord injury; Functional outcome; Biomarker; Serum zinc concentration
资金
- JSPS KAKENHI [JP18K16680, 16H05450]
- Challenging Exploratory Research from the Ministry of Education, Science, and Sports [16K15668]
- AMED [19gm6210003h0002]
- general insurance association of Japan
- Grants-in-Aid for Scientific Research [16H05450] Funding Source: KAKEN
Background: Spinal cord injury (SCI) is a devastating disorder for which the accurate prediction of the functional prognosis is urgently needed. Due to the lack of reliable prediction methods, the acute evaluation of SCI severity and therapeutic intervention efficacy is extremely difficult, presenting major obstacles to the development of acute SCI treatment. We herein report a novel method for accurately predicting the functional prognosis using the acute-phase serum zinc concentration after SCI. Methods: Weproduced experimental animal SCImodelswith different prognoses and examined the relationship among the SCI severity, functional outcome, and acute-phase serum zinc concentration. We also examined whether we could predict the functional prognosis by evaluating the serum zinc concentration within 72 h after SCI in a human prospective study. Findings: In amouse model, the acute serumzinc concentrations decreased in proportion to SCI severity and the serumzinc concentrations at 12 h after SCI accurately predicted the functional prognosis. We clarified themechanism underlying this serum zinc proportional decrease, showing that activated monocytes took up zinc from blood-serum and then infiltrated the lesion area in a severity-dependent manner. A non-linear regression analysis of 38 SCI patients showed that the serum zinc concentrations in the acute-phase accurately predicted the long-termfunctional outcome (R-2=0.84) more accurately than any other previously reported acute-phase biomarkers. Interpretation: The acute-phase serum zinc concentration could be a useful biomarker for predicting the functional prognosis. This simple method will allow for more objective clinical trials and the development of patient-tailored treatment for SCI. (c) 2019 The Authors. Published by Elsevier B. V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据