期刊
SCIENCE ADVANCES
卷 5, 期 3, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciadv.aav5335
关键词
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资金
- NSFC [91544218, 61427818, 11774330, 21574120, 21774115]
- MOST [2016YFA0200601, 2013CBA01703]
- Science and Technological Fund of Anhui Province for Outstanding Youth [1608085J02, 1608085J01]
- Longshan Academic Talent Research Supporting program of SWUST [17LZX626]
- Fundamental Research Funds for the Central Universities [WK2340000084, WK2030380008]
- Anhui Provincial Science and Technology Major Projects [18030901005]
- Anhui Initiative in Quantum Information Technologies
- foundation of Key Laboratory of Environmental Optics and Technology of Chinese Academy of Sciences [2005DP173065-2019-XX]
- National Institute of Health [GM125976, GM129561, EB018959, S10OD019975]
Surface plasmon resonance microscopy (SPRM) with single-direction illumination is a powerful platform for biomedical imaging because of its wide-field, label-free, and high-surface-sensitivity imaging capabilities. However, two disadvantages prevent wider use of SPRM. The first is its poor spatial resolution that can be as large as several micrometers. The second is that SPRM requires use of metal films as sample substrates; this introduces working wavelength limitations. In addition, cell culture growth on metal films is not as universally available as growth on dielectric substrates. Here we show that use of azimuthal rotation illumination allows SPRM spatial resolution to be enhanced by up to an order of magnitude. The metal film can also be replaced by a dielectric multilayer and then a different label-free surface-sensitive photonic microscopy is developed, which has more choices in terms of the working wavelength, polarization, and imaging section, and will bring opportunities for applications in biology.
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