期刊
SCIENCE ADVANCES
卷 5, 期 3, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciadv.aav3687
关键词
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资金
- Swiss National Science Foundation (SNSF) [320030_176222]
- Mach-Gaensslen Stiftung
- Stiftung fur wissenschaftliche Forschung an der Universitat Zurich
- Forschungskredit der Universitat Zurich
- Swiss National Science Foundation (SNF) [320030_176222] Funding Source: Swiss National Science Foundation (SNF)
The maintenance of items in working memory relies on persistent neural activity in a widespread network of brain areas. To investigate the influence of load on working memory, we asked human subjects to maintain sets of letters in memory while we recorded single neurons and intracranial encephalography (EEG) in the medial temporal lobe and scalp EEG. Along the periods of a trial, hippocampal neural firing differentiated between success and error trials during stimulus encoding, predicted workload during memory maintenance, and predicted the subjects' behavior during retrieval. During maintenance, neuronal firing was synchronized with intracranial hippocampal EEG. On the network level, synchronization between hippocampal and scalp EEG in the theta-alpha frequency range showed workload dependent oscillatory coupling between hippocampus and cortex. Thus, we found that persistent neural activity in the hippocampus participated in working memory processing that is specific to memory maintenance, load sensitive and synchronized to the cortex.
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