期刊
CHEM
卷 5, 期 5, 页码 1059-1107出版社
CELL PRESS
DOI: 10.1016/j.chempr.2019.01.006
关键词
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资金
- National Natural Science Foundation of China [21302171, 21576062, 21871071]
- Zhejiang Provincial Natural Science Foundation of China [LY17B020005]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT 1231]
- National Research Foundation of the Singapore Prime Minister's Office through its Competitive Research Program [NRF-CRP15-2015-03]
The 4-quinolones and their analogs are a heterogeneous group of biologically active compounds that have evolved in modern days to provide utilities at the forefront of antibiotic research. They have been used to combat Gram-negative orGram-positive bacteria, suppress tumor growth, and treatmany serious infections. These antimicrobial agents have also been used to promote apoptosis and DNA repair for the treatment of cancer. This review summarizes the experimental progress made in the synthetic development of various catalytic routes to preparing 4-quinolones and their analogs; discusses our current understanding of the reaction mechanisms involving biocatalytic synthesis, general catalytic synthesis, and asymmetric synthesis; and finally presents the future prospects of the emerging field.
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